Dermatopathology Department, Geisinger Medical Center, Danville, Pennsylvania, USA.
Dermatology Department, Geisinger Medical Center, Danville, Pennsylvania, USA.
J Cutan Pathol. 2023 Oct;50(10):884-889. doi: 10.1111/cup.14487. Epub 2023 Jul 4.
Fixed drug eruption (FDE) is an adverse drug reaction characterized by recurrent circumscribed lesions at the same location upon re-exposure to the culprit medication, resulting in distinct postinflammatory hyperpigmentation. Histopathologically, FDE demonstrates a predominantly lymphocytic interface or lichenoid infiltrate with basal cell vacuolar changes and keratinocyte dyskeratosis/apoptosis. The term "neutrophilic fixed drug eruption" has been used to describe cases in which the inflammatory infiltrate is predominantly neutrophilic. The infiltrate can extend deeper in the dermis, potentially mimicking a neutrophilic dermatosis such as Sweet syndrome. We present two cases and review the literature to discuss the possibility that a neutrophilic inflammatory infiltrate may be an expected finding in FDE, rather than a histopathologic variant.
固定型药物疹（FDE）是一种药物不良反应，其特征是在再次接触致敏药物时，同一部位反复出现局限性皮损，导致明显的炎症后色素沉着过度。组织病理学上，FDE 表现为以淋巴细胞为主的界面或苔藓样浸润，伴有基底细胞空泡化和角质形成细胞角化不良/凋亡。“嗜中性粒细胞固定型药物疹”一词用于描述以嗜中性粒细胞浸润为主的病例。浸润可在真皮深层延伸，可能类似于中性粒细胞皮肤病，如Sweet 综合征。我们报告两例病例并复习文献，讨论嗜中性粒细胞炎症浸润可能是 FDE 的一种预期表现，而不是组织病理学变异。
