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红细胞分布宽度和伸长指数在青少年急性心肌梗死患者队列中的研究。

Red Cell Distribution Width and Elongation Index in a Cohort of Patients With Juvenile Acute Myocardial Infarction.

机构信息

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.

Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

出版信息

Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231186148. doi: 10.1177/10760296231186148.

Abstract

In a cohort of patients with juvenile myocardial infarction, we considered the red cell distribution width (RDW), hematocrit, hemoglobin, and elongation index values at the initial phase and at 3 and 12 months from the acute event. In the initial phase, only the elongation index values turn out reduced if compared with those of the control group, and that only turn out to discriminate the infarcted ST-segment elevation myocardial infarction (STEMI) from non-STEMI. Dividing the patients according to the traditional risk factors and the extent of coronary heart disease, there are no significant variations in the analyzed parameters. No major changes are observed after 12 months from the acute event. Both to 3 and to 12 months from the infarct episode, the negative statistical correlation between RDW and the value of elongation index remains. These data make us reflect on the role of the degree of anisocytosis of red blood cell expressed by the RDW on the determinism of erythrocyte deformability, which plays its role in the microcirculation district and that is essential in the transfer of tissue oxygen.

摘要

在一组青少年心肌梗死患者中,我们考虑了初始阶段以及急性事件后 3 个月和 12 个月时的红细胞分布宽度(RDW)、血细胞比容、血红蛋白和伸长指数值。在初始阶段,与对照组相比,只有伸长指数值降低,并且仅能区分梗死的 ST 段抬高型心肌梗死(STEMI)和非 ST 段抬高型心肌梗死(NSTEMI)。根据传统危险因素和冠心病程度对患者进行分组,分析参数无明显差异。急性事件后 12 个月无明显变化。从梗塞发作到 3 个月和 12 个月,RDW 与伸长指数值之间仍然存在负统计学相关性。这些数据使我们思考 RDW 所表示的红细胞各向异性程度在红细胞变形性决定中的作用,红细胞变形性在微循环区起作用,对组织供氧至关重要。

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