Ren Huiwen, Wu Qi, Sun Zhiqiang, Fang Mingming, Liu Jun, Luo Judong
Department of Radiotherapy, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, China.
Department of Radiotherapy, Graduate School of Dalian Medical University, Dalian, China.
Radiat Oncol J. 2023 Jun;41(2):61-68. doi: 10.3857/roj.2023.00346. Epub 2023 Jun 28.
Radiation enteritis is a kind of intestinal radiation injury in patients with pelvic and retroperitoneal malignancies after radiotherapy, and its occurrence and development process are very complicated. At present, studies have confirmed that intestinal microecological imbalance is an important factor in the formation of this disease. Abdominal radiation causes changes in the composition of the flora and a decrease in its diversity, which is mainly manifested by a decrease in beneficial bacterial species such as Lactobacilli and Bifidobacteria. Intestinal dysbacteriosis aggravates radiation enteritis, weakens the function of the intestinal epithelial barrier, and promotes the expression of inflammatory factors, thereby aggravating the occurrence of enteritis. Given the role of the microbiome in radiation enteritis, we suggest that the gut microbiota may be a potential biomarker for the disease. Treatment methods such as probiotics, antibiotics, and fecal microbiota transplantation are ways to correct the microbiota and may be an effective way to prevent and treat radiation enteritis. Based on a review of the relevant literature, this paper reviews the mechanism and treatment of intestinal microbes in radiation enteritis.
放射性肠炎是盆腔和腹膜后恶性肿瘤患者放疗后发生的一种肠道放射性损伤，其发生发展过程非常复杂。目前，研究已证实肠道微生态失衡是该疾病形成的重要因素。腹部放疗会导致菌群组成发生变化，其多样性降低，主要表现为有益菌如乳酸杆菌和双歧杆菌等种类减少。肠道菌群失调会加重放射性肠炎，削弱肠道上皮屏障功能，促进炎症因子表达，从而加重肠炎的发生。鉴于微生物群在放射性肠炎中的作用，我们认为肠道微生物群可能是该疾病的一个潜在生物标志物。益生菌、抗生素和粪便微生物群移植等治疗方法是纠正微生物群的途径，可能是预防和治疗放射性肠炎的有效方法。基于对相关文献的综述，本文对放射性肠炎中肠道微生物的作用机制及治疗进行综述。
