Solli District Psychiatric Centre, Nesttun, Norway.
Institute for Clinical Psychology, University of Bergen, Bergen, Norway.
Cogn Behav Neurol. 2023 Dec 1;36(4):219-227. doi: 10.1097/WNN.0000000000000349.
Brain-derived neurotrophic factor (BDNF) expression, which can be measured in blood serum, has been found to increase with aerobic exercise. The link between BDNF level, physical exercise, and genetic status (Val66Met polymorphism) has not been well researched in older adults.
To investigate the possible link between BDNF expression, acute aerobic exercise, and the Val66Met polymorphism in older adults.
Twenty-three healthy older adults participated in one session of acute aerobic exercise. Their serum BDNF levels were measured both at baseline and post exercise. Saliva samples were collected to identify each individual's genetic status.
At baseline, the individuals' mean serum BDNF level was 16.03 ng/mL (Val66Val = 15.89 ng/mL; Val66Met = 16.34 ng/mL); post exercise, the individuals' mean serum BDNF level was 16.81 ng/mL (Val66Val = 16.14 ng/mL; Val66Met = 18.34 ng/mL).
One session of acute aerobic exercise significantly increased the individuals' mean serum BDNF level. Males had higher BDNF levels than females. There was a significant interaction between gender and BDNF expression post exercise and a significant between-group effect of gender. The Val66Met carriers had a more positive response to the acute aerobic exercise compared with the Val66Val carriers, although without a significant difference between the two groups.
在血清中可测量到的脑源性神经营养因子（BDNF）表达随着有氧运动而增加。BDNF 水平、体育锻炼和遗传状态（Val66Met 多态性）之间的联系在老年人中尚未得到充分研究。
探讨老年人群中 BDNF 表达、急性有氧运动与 Val66Met 多态性之间的可能联系。
23 名健康老年人参加了一次急性有氧运动。他们的血清 BDNF 水平在基线和运动后均进行了测量。采集唾液样本以确定每个个体的遗传状态。
基线时，个体的平均血清 BDNF 水平为 16.03ng/ml（Val66Val=15.89ng/ml；Val66Met=16.34ng/ml）；运动后，个体的平均血清 BDNF 水平为 16.81ng/ml（Val66Val=16.14ng/ml；Val66Met=18.34ng/ml）。
一次急性有氧运动显著增加了个体的平均血清 BDNF 水平。男性的 BDNF 水平高于女性。运动后性别与 BDNF 表达之间存在显著的交互作用，性别存在显著的组间效应。与 Val66Val 携带者相比，Val66Met 携带者对急性有氧运动的反应更为积极，尽管两组之间没有显著差异。
