Mohammad Retaj, Crimmins Darach
Department of Neurosurgery, Children's Health Ireland at Temple St, Dublin, Ireland.
Surg Neurol Int. 2023 Jun 16;14:209. doi: 10.25259/SNI_249_2023. eCollection 2023.
Brainstem located abscesses are rare in the pediatric population. Diagnosis of brain abscess can be challenging as patients may present with nonspecific symptoms and the classical triad of headache, fever, and focal neurological deficit is not always present. Treatment can be conservative or a combination of surgical intervention with antimicrobial therapy.
We present the first case of a 4.5-year-old girl with acute lymphoblastic leukemia that developed infective endocarditis (IE) and subsequently developed 3 suppurative collections (frontal, temporal, and brainstem). The patient had negative cerebrospinal, blood, and pus culture growth and subsequently underwent burr-hole drainage of the frontal and temporal abscesses with a 6-week course of intravenous antibiotic therapy with an uneventful postoperative course. At 1 year, the patient is left with minor right lower limb hemiplegia and no cognitive sequelae.
The decision to surgically intervene for brainstem abscesses is dependent on surgeon and patient factors including the presence of multiple collections, midline shift, the aim of source identification in sterile cultures, and the patient's neurological condition. Patients with hematological malignancies should be monitored closely for IE which is a risk factor for hematogenous spread of brainstem located abscesses.
脑干脓肿在儿科人群中较为罕见。脑脓肿的诊断具有挑战性,因为患者可能表现出非特异性症状,且头痛、发热和局灶性神经功能缺损的典型三联征并不总是出现。治疗可以是保守治疗,也可以是手术干预与抗菌治疗相结合。
我们报告了首例4.5岁急性淋巴细胞白血病女童,该患儿发生感染性心内膜炎(IE),随后出现3个化脓性病灶(额叶、颞叶和脑干)。患者脑脊液、血液和脓液培养均为阴性,随后对额叶和颞叶脓肿进行了钻孔引流,并进行了为期6周的静脉抗生素治疗,术后过程顺利。1年后,患者遗留轻度右下肢偏瘫,无认知后遗症。
对脑干脓肿进行手术干预的决定取决于外科医生和患者因素,包括多个病灶的存在、中线移位、无菌培养中确定感染源的目的以及患者的神经状况。血液系统恶性肿瘤患者应密切监测IE,因为IE是脑干脓肿血行播散的危险因素。