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免疫功能正常的青少年男性同时发生脑脓肿和脊髓脓肿:病例说明

Concomitant brain abscess and spinal cord abscess in an immunocompetent teenage male: illustrative case.

作者信息

Virtanen Piiamaria S, Jimenez Med Jimson D, Horak V Jane, Desai Virendra R, Manaloor John J, Raskin Jeffrey S

机构信息

1Department of Neurological Surgery, Section of Pediatric Neurosurgery, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana.

2Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.

出版信息

J Neurosurg Case Lessons. 2023 Jan 23;5(4). doi: 10.3171/CASE22458.

Abstract

BACKGROUND

Multiple bilateral brain abscesses occur rarely in immunocompetent patients. Hematogenous spread to the central nervous system (CNS) allows suppuration and abscess formation in the privileged immune environment of the CNS; hematogenous spread to the spinal cord is extremely rare and the combination of multifocal brain abscesses and intramedullary abscesses has not been reported. This report presents a rare presentation and diagrams a treatment algorithm involving iterative minimal access surgeries and prolonged medical management.

OBSERVATIONS

The authors present a case of an 18-year-old male with numerous multifocal and bilateral intraparenchymal abscesses and a medically resistant C5 intramedullary spinal cord abscess. The symptomatic patient had a left oculomotor palsy and left hemiparesis, ultimately undergoing ultrasound-guided aspiration of abscesses in the left frontal and left cerebral peduncle. Following transient motor improvement, he evolved tetraparesis prompting spinal cord imaging and emergent ultrasound-guided needle aspiration of an occult C5 intramedullary spinal cord abscess. The patient received appropriate medical therapy, completed inpatient rehabilitation, and made a full recovery.

LESSONS

Needle- and ultrasound-guided catheter drainage of CNS abscesses should be considered for symptomatic lesions. Following the neurological examination closely is extremely important; if the expected neurological improvement is delayed or regresses, then expanded imaging is warranted.

摘要

背景

免疫功能正常的患者很少发生多发性双侧脑脓肿。血行播散至中枢神经系统(CNS)可在CNS特殊的免疫环境中导致化脓和脓肿形成;血行播散至脊髓极为罕见,多灶性脑脓肿和髓内脓肿并存的情况尚未见报道。本报告介绍了一种罕见病例,并绘制了一种治疗方案,包括反复进行的微创手术和长期的药物治疗。

观察结果

作者报告了一例18岁男性患者,患有多处多灶性双侧脑实质内脓肿以及对药物治疗耐药的C5节段髓内脊髓脓肿。该有症状的患者出现左侧动眼神经麻痹和左侧偏瘫,最终接受了超声引导下对左侧额叶和左侧大脑脚脓肿的穿刺抽吸。短暂的运动功能改善后,他发展为四肢瘫,促使进行脊髓成像检查,并紧急通过超声引导对隐匿性C5节段髓内脊髓脓肿进行针吸。患者接受了适当的药物治疗,完成了住院康复治疗,最终完全康复。

经验教训

对于有症状的病变,应考虑采用针吸和超声引导下的导管引流治疗CNS脓肿。密切随访神经系统检查极为重要;如果预期的神经功能改善延迟或出现倒退,则有必要进行更广泛的影像学检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acae/10550703/b6bbeb6fc153/CASE22458f1.jpg

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