Matsui Masanori, Kawamura Kahori, Kano Keita, Yoshimatsu Hideki, Doi Takashi, Miyake Tatsuro
Graduate School of Dentistry (Department of Preventive and Community Dentistry), Osaka Dental University, Hirakata, Osaka, Japan.
Department of Preventive and Community Dentistry, Osaka Dental University, Hirakata, Osaka, Japan.
J Dent Sci. 2023 Jul;18(3):1047-1054. doi: 10.1016/j.jds.2022.11.025. Epub 2022 Dec 9.
BACKGROUND/PURPOSE: As the occurrence of second primary cancers (SPCs) is strongly related to the survival rate of patients with oral and pharyngeal cancers, early detection and treatment are important. Therefore, this study aimed to clarify the incidence of SPCs and their risk factors in patients with oral and pharyngeal cancer.
This observational study was conducted using data from the administrative claims database of 21,736 participants with oral and pharyngeal cancer from January 2005 to December 2020. We evaluated the cumulative incidence of SPCs among patients with oral and pharyngeal cancers using the Kaplan-Meier method. The Cox proportional-hazard model was used for multivariate analysis.
Of the 1633 patients with oral and pharyngeal cancer who qualified for analysis, 388 developed SPCs (incidence rate, 7.994/1000 person-months). The multivariate analysis showed that the risk of developing SPCs was affected by age at diagnosis of oral and pharyngeal cancer, cancer treatment, and anatomical site of the primary cancer.
Patients with oral and pharyngeal cancers are at a high risk of developing SPCs. The data from this study may be useful in providing accurate information to patients with oral and oropharyngeal cancer.
背景/目的：由于第二原发性癌症（SPCs）的发生与口腔和咽癌患者的生存率密切相关，早期发现和治疗至关重要。因此，本研究旨在阐明口腔和咽癌患者中SPCs的发病率及其危险因素。
本观察性研究使用了2005年1月至2020年12月期间21736名口腔和咽癌参与者的行政索赔数据库中的数据。我们使用Kaplan-Meier方法评估口腔和咽癌患者中SPCs的累积发病率。Cox比例风险模型用于多变量分析。
在1633名符合分析条件的口腔和咽癌患者中，388人发生了SPCs（发病率为7.994/1000人月）。多变量分析表明，发生SPCs的风险受口腔和咽癌诊断时的年龄、癌症治疗以及原发癌的解剖部位影响。
口腔和咽癌患者发生SPCs的风险很高。本研究的数据可能有助于为口腔和口咽癌患者提供准确信息。
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