Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.
Front Immunol. 2023 Jun 19;14:1187890. doi: 10.3389/fimmu.2023.1187890. eCollection 2023.
The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc. It has been reported that various TRP channels are expressed in mammalian macrophages. TRP channels may be involved in various signaling pathways in the development of various systemic diseases through changes in intracellular concentrations of cations such as calcium and magnesium. These TRP channels may also intermingle with macrophage activation signals to jointly regulate the occurrence and development of diseases. Here, we summarize recent findings on the expression and function of TRP channels in macrophages and discuss their role as modulators of macrophage activation and function. As research on TRP channels in health and disease progresses, it is anticipated that positive or negative modulators of TRP channels for treating specific diseases may be promising therapeutic options for the prevention and/or treatment of disease.
瞬时受体电位通道（TRP 通道）家族是一种广泛分布于人体各种组织和器官的非特异性阳离子通道，包括呼吸系统、心血管系统、免疫系统等。据报道，各种 TRP 通道在哺乳动物巨噬细胞中表达。TRP 通道可能通过改变细胞内钙、镁等阳离子的浓度，参与各种系统性疾病的发展过程中的各种信号通路。这些 TRP 通道也可能与巨噬细胞激活信号交织在一起，共同调节疾病的发生和发展。在这里，我们总结了 TRP 通道在巨噬细胞中的表达和功能的最新发现，并讨论了它们作为巨噬细胞激活和功能调节剂的作用。随着对 TRP 通道在健康和疾病中的研究进展，TRP 通道的阳性或阴性调节剂可能是治疗特定疾病的有前途的治疗选择，可用于疾病的预防和/或治疗。
