Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China.
Front Immunol. 2023 Jun 19;14:1203719. doi: 10.3389/fimmu.2023.1203719. eCollection 2023.
One pivotal aspect of early pregnancy is decidualization. The decidualization process includes two components: the differentiation of endometrial stromal cells to decidual stromal cells (DSCs), as well as the recruitment and education of decidual immune cells (DICs). At the maternal-fetal interface, stromal cells undergo morphological and phenotypic changes and interact with trophoblasts and DICs to provide an appropriate decidual bed and tolerogenic immune environment to maintain the survival of the semi-allogeneic fetus without causing immunological rejection. Despite classic endocrine mechanism by 17 β-estradiol and progesterone, metabolic regulations do take part in this process according to recent studies. And based on our previous research in maternal-fetal crosstalk, in this review, we elaborate mechanisms of decidualization, with a special focus on DSC profiles from aspects of metabolism and maternal-fetal tolerance to provide some new insights into endometrial decidualization in early pregnancy.
妊娠早期的一个关键方面是蜕膜化。蜕膜化过程包括两个部分：子宫内膜基质细胞向蜕膜基质细胞（DSC）的分化，以及蜕膜免疫细胞（DIC）的募集和教育。在母体-胎儿界面，基质细胞发生形态和表型变化，并与滋养层细胞和 DIC 相互作用，为半同种异体胎儿的存活提供适当的蜕膜床和耐受免疫环境，而不会引起免疫排斥。尽管经典的内分泌机制是由 17β-雌二醇和孕激素介导的，但根据最近的研究，代谢调节也参与了这个过程。基于我们之前在母体-胎儿串扰方面的研究，在这篇综述中，我们详细阐述了蜕膜化的机制，特别关注 DSC 从代谢和母体-胎儿耐受方面的特征，为早期妊娠的子宫内膜蜕膜化提供一些新的见解。
