Makabe Shunta, Koguchi Tomoyuki, Matsuoka Kanako, Hoshi Seiji, Hata Junya, Sato Yuichi, Akaihata Hidenori, Kataoka Masao, Uemura Motohide, Kojima Yoshiyuki
Department of Urology Fukushima Medical University School of Medicine Fukushima Japan.
IJU Case Rep. 2023 Jun 14;6(4):248-252. doi: 10.1002/iju5.12598. eCollection 2023 Jul.
Basal cell carcinoma of the prostate is rare, with no established treatment for its recurrence or metastasis. We report a case involving basal cell carcinoma of the prostate controlled using radiotherapy.
A 57-year-old man complained of perineal pain. Although his prostate-specific antigen was 0.657 ng/mL, a digital rectal examination revealed his prostate was stone hard. Prostate needle biopsy showed basal cell carcinoma of the prostate. The patient then underwent radical prostatectomy. Local recurrence and sacral bone metastasis appeared 2 months after surgery. OncoGuide™ NCC Oncopanel System showed deletion of ; however no recommended treatment was identified. Thus, we decided to perform radiotherapy, which reduced all lesions.
Basal cell carcinoma of the prostate may have a poor prognosis with recurrence or metastasis, hence evaluation of prognostic factors is important. In this case, the genomic profiling test suggested that deletion may be a prognostic factor associated with disease progression.
前列腺基底细胞癌罕见，其复发或转移尚无既定的治疗方法。我们报告一例采用放射治疗控制前列腺基底细胞癌的病例。
一名57岁男性主诉会阴部疼痛。尽管其前列腺特异性抗原为0.657 ng/mL，但直肠指检显示其前列腺坚硬如石。前列腺穿刺活检显示为前列腺基底细胞癌。该患者随后接受了前列腺根治术。术后2个月出现局部复发和骶骨转移。OncoGuide™ NCC Oncopanel系统显示有缺失；然而未发现推荐的治疗方法。因此，我们决定进行放射治疗，所有病灶均缩小。
前列腺基底细胞癌复发或转移时预后可能较差，因此评估预后因素很重要。在本病例中，基因谱检测提示缺失可能是与疾病进展相关的预后因素。
