胆汁酸调节 MAdCAM-1 的表达，将肠道微生物群与癌症免疫监视联系起来。
Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance.
机构信息
Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France.
Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.
出版信息
Oncoimmunology. 2023 Jun 29;12(1):2224672. doi: 10.1080/2162402X.2023.2224672. eCollection 2023.
Abstract
In a recent paper in , Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM-1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.
摘要
在最近发表于 的一篇论文中，Fidelle 等人揭示了一种被抗生素治疗颠覆的肠道免疫检查点。抗生素治疗后的回肠菌群失调会导致胆汁酸增加，从而下调 MAdCAM-1，进而触发免疫抑制性 T 细胞从肠道相关淋巴组织向肿瘤迁移。
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