Department of Lymphoma and Hematology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.
Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, Hunan, People's Republic of China.
Drug Des Devel Ther. 2023 Jun 28;17:1933-1943. doi: 10.2147/DDDT.S417563. eCollection 2023.
Moving a new drug from bench to bedside is a long and arduous process. The tactic of drug repurposing, which solves "new" diseases with "old" existing drugs, is more efficient and economical than conventional ab-initio way for drug development. Information technology has dramatically changed the paradigm of biomedical research in the new century, and drug repurposing studies have been significantly accelerated by implementing informatics techniques related to genomics, systems biology and biophysics during the past few years. A series of remarkable achievements in this field comes with the practical applications of in silico approaches including transcriptomic signature matching, gene-connection-based scanning, and simulated structure docking in repositioning drug therapies against breast cancer. In this review, we systematically curated these impressive accomplishments with summarization of the main findings on potentially repurposable drugs, and provide our insights into the current issues as well as future directions of the field. With the prospective improvement in reliability, the computer-assisted repurposing strategy will play a more critical role in drug research and development.
将新药从实验室推向临床是一个漫长而艰巨的过程。药物重定位策略用现有药物治疗“新”疾病比传统的从头开始药物开发方法更有效和经济。信息技术在新世纪极大地改变了生物医学研究的模式，在过去几年中，通过实施与基因组学、系统生物学和生物物理学相关的信息学技术，药物重定位研究得到了显著加速。该领域的一系列显著成就伴随着计算方法的实际应用，包括转录组特征匹配、基于基因连接的扫描以及模拟结构对接在重新定位乳腺癌治疗药物中的应用。在这篇综述中，我们系统地整理了这些令人印象深刻的成果，总结了潜在可重定位药物的主要发现，并对该领域当前的问题和未来的方向提出了我们的见解。随着可靠性的预期提高，计算机辅助重定位策略将在药物研究和开发中发挥更关键的作用。
