George C E, Grimsley S, Cumber R, Thornton N, Davies H, Harris C, Massey E, Perera K
MSc, FBBTS, DipFRCPath, Principal Clinical Scientist in Transfusion Medicine (Head of Component Development), Welsh Blood Service, Ely Valley Road, Talbot Green, Llantrisant, CF72 9WB, UK.
DipRCPath, Senior Clinical Scientist (HSST), International Blood Group Reference Laboratory, NHS Blood and Transplant, Bristol, UK.
Immunohematology. 2023 Jul 5;39(2):70-71. doi: 10.21307/immunohematology-2023-011. eCollection 2023 Jun 1.
Sc1 is a high-prevalence blood group antigen that is part of the Scianna blood group system. The clinical significance of Scianna antibodies is not well understood because of their rarity; there are only a handful of cases in the literature. This scarcity of information can make it difficult to decide on the best course of action when transfusing a patient with alloantibodies to Scianna blood group antigens. We describe a case of an 85-year-old woman presenting with melena and a hemoglobin of 66 g/L. Upon request for crossmatched blood, a panreactive antibody was found, later elucidated to be alloanti-Sc1. Because of the urgent nature of the transfusion, the patient was transfused with 2 incompatible, presumed Sc1+, red blood cell units with no evidence of an acute or delayed transfusion reaction. This case has been shared with the International Society of Blood Transfusion Rare Donor Working Party, via their Outcome of Incompatible Transfusion form, and adds to the body of evidence on clinical significance of antibodies to the antigens of the Scianna blood group system.
Sc1是一种高频率血型抗原，属于斯恰纳血型系统。由于斯恰纳抗体十分罕见，其临床意义尚未得到充分了解；文献中仅有少数病例报道。在为携带斯恰纳血型抗原同种抗体的患者输血时，这种信息匮乏会使确定最佳治疗方案变得困难。我们报告一例85岁女性患者，出现黑便，血红蛋白水平为66 g/L。在申请交叉配血时，发现一种泛反应性抗体，后来确定为抗Sc1同种抗体。由于输血需求紧急，该患者输注了2个不相容的、推测为Sc1阳性的红细胞单位，未出现急性或迟发性输血反应迹象。该病例已通过国际输血协会稀有供体工作组的不相容输血结果表格进行分享，为斯恰纳血型系统抗原抗体临床意义的证据库增添了内容。
