Brunker Patricia A R, Flegel Willy A
Medical Director, American Red Cross, Biomedical Services, Greater Chesapeake and Potomac Region.
Chief, Laboratory Services Section, DTM/CC/NIH, Bethesda, MD.
Immunohematology. 2019 Jun;35(2):48-50.
This update of the Scianna blood group system (Brunker PA, Flegel WA. Scianna: the lucky 13th blood group system. Immunohematology 2011;27:41-57) provides the recent work on the genetic variation of ERMAP across more world populations, the elucidation of the molecular basis of an historical serologic case, new cases of antibodies in the system, the development of new serologic reagents, and new discoveries in the biology of the erythroid membrane associated protein (ERMAP). Although genetic variation in ERMAP has been extensively cataloged, nonsynonymous variants associated with alloantigens have remained limited, and no new antigens have been identified. The first case of a severe hemolytic transfusion reaction to anti-Sc2 has recently been reported, highlighting the importance of pursuing the possibility of antibodies to low-prevalence antigens via indirect antiglobulin testing as a routine component of all transfusion reaction investigations. The expanding use of molecular testing in blood centers and transfusion services has uncovered a wider population distribution of Scianna antigens and heightened the awareness of this blood group system. The International Society of Blood Transfusion recognizes seven antigens in the Scianna blood group system 13.
本次对斯恰纳血型系统的更新（布伦克 PA，弗莱格尔 WA。斯恰纳：第 13 个幸运血型系统。免疫血液学 2011；27：41 - 57）介绍了关于红细胞膜相关蛋白（ERMAP）在更多世界人群中的遗传变异的最新研究、对一例历史血清学病例分子基础的阐明、该系统中抗体的新病例、新型血清学试剂的开发以及在红细胞膜相关蛋白（ERMAP）生物学方面的新发现。尽管 ERMAP 的遗传变异已被广泛编目，但与同种抗原相关的非同义变异仍然有限，且未发现新的抗原。最近报道了首例针对抗 - Sc2 的严重溶血性输血反应病例，凸显了在所有输血反应调查中，通过间接抗球蛋白试验追查针对低频率抗原的抗体可能性的重要性，将其作为常规组成部分。血液中心和输血服务机构对分子检测的使用不断增加，发现了斯恰纳抗原更广泛的人群分布，并提高了对该血型系统的认识。国际输血协会在斯恰纳血型系统中认可七种抗原 13。
