癌症研究史：逆转录病毒插入突变。
A History of Cancer Research: Retroviral Insertional Mutagenesis.
机构信息
Departments of Pathology, Genetics, and Biology, Stanford University, Stanford, California 94305-5324, USA
出版信息
Cold Spring Harb Perspect Biol. 2023 Jul 5;15(7):a035873. doi: 10.1101/cshperspect.a035873.
Early work on cancer showed that some retroviruses contain oncogenes that promote tumorigenesis, but how viruses that do not contain oncogenes could cause cancer was unclear. A series of studies in the 1980s uncovered another mechanism: insertional mutagenesis in which viral sequences drove aberrant expression of endogenous cellular proto-oncogenes. In this excerpt from his forthcoming book on the history of cancer research, Joe Lipsick looks back at these discoveries, how the work led to identification of new oncogenes and tumor suppressors, and the perils of the phenomenon for early gene therapy.
早期的癌症研究表明，一些逆转录病毒含有致癌基因，可促进肿瘤发生，但不含有致癌基因的病毒如何致癌尚不清楚。20 世纪 80 年代的一系列研究揭示了另一种机制：插入突变，其中病毒序列驱动内源性细胞原癌基因的异常表达。在即将出版的关于癌症研究史的书中，乔·利普西克（Joe Lipsick）回顾了这些发现，以及这些工作如何导致新的致癌基因和肿瘤抑制基因的鉴定，以及这一现象对早期基因治疗的危害。
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