莫洛尼鼠白血病病毒引发白血病：一个多步骤过程。
Leukemogenesis by Moloney murine leukemia virus: a multistep process.
作者信息
Fan H
机构信息
Dept of Molecular Biology, University of California, Irvine 92717, USA.
出版信息
Trends Microbiol. 1997 Feb;5(2):74-82. doi: 10.1016/S0966-842X(96)10076-7.
PMID:9108934
Abstract
Moloney murine leukemia virus is a prototypical simple retrovirus that has been an extremely useful model for leukemogenesis. Important steps in leukemogenesis include proviral activation of cellular proto-oncogenes, generation of mink cell focus-inducing recombinants, and early (preleukemic) virus-induced changes in hematopoiesis.
摘要
莫洛尼鼠白血病病毒是一种典型的简单逆转录病毒，它一直是白血病发生研究中极为有用的模型。白血病发生的重要步骤包括细胞原癌基因的前病毒激活、水貂细胞集落诱导重组体的产生，以及早期（白血病前期）病毒诱导的造血变化。
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