Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel, Switzerland.
Anal Chem. 2023 Jul 18;95(28):10777-10784. doi: 10.1021/acs.analchem.3c01898. Epub 2023 Jul 5.
An easily built drift tube instrument with ring electrodes made of rolled-up flexible printed circuit boards is reported. Its resolving power was maximized by careful attention to the drift tube geometry and the response time of the detector amplifier and by employing a high separation field strength. The separation of singly charged aliphatic quaternary ammonium ions introduced by electrospray was performed, and the measured resolving power was between 86 and 97% of the theoretical limit for three different drift tube lengths investigated. For the longest drift length of 30 cm, a resolving power of up to 228 was obtained. Three benzalkonium chlorides were also separated with resolving powers of over 210. The tristate injection scheme can also be used, with only a small loss of the separation performance compared to the two-state injection.
报道了一种采用卷绕式柔性印刷电路板制成的环形电极的易于构建的漂移管仪器。通过仔细关注漂移管几何形状和探测器放大器的响应时间，并采用高分离场强，最大限度地提高了其分辨率。通过电喷雾引入的单电荷脂肪族季铵离子进行了分离，在所研究的三种不同漂移管长度中，测量的分辨率在理论极限的 86%至 97%之间。对于最长的 30 厘米漂移长度，获得了高达 228 的分辨率。三种苯扎氯铵也实现了超过 210 的分辨率。与两态注入相比，三态注入方案的分离性能仅略有下降。
