Department of Chemistry, Washington State University, Pullman, Washington 99164, United States.
J Am Soc Mass Spectrom. 2023 Apr 5;34(4):586-594. doi: 10.1021/jasms.2c00308. Epub 2023 Mar 14.
As the spectrum of ion mobility spectrometry (IMS) applications expands and more experimental configurations are developed, identifying the correct platform for an experimental campaign becomes more challenging for researchers. Additionally, metrics that compare performance ( for example) often have nuanced differences in definition between platforms that render direct comparisons difficult. Here we present a comparison of three do-it-yourself (DIY) drift tubes that are relatively low cost and easy to construct, where the performance of each is evaluated based on three different metrics: resolving power, the ideality of resolving powers, and accuracy/precision of values. The standard PCBIMS design developed by Reinecke and Clowers (Reinecke, T.; Clowers, B. H. 2018, 4, e00030) provided the highest resolving power (>90) and the highest ideality of resolving power ratios (>90% at best) of the three systems. However, the flexible tube (FlexIMS) construction as described by Smith et al. (Smith, B. L. 2020, 92 (13), 9104-9112) exhibited the highest degree of precision of values (relative standard deviation of <0.42%). Depending on the application, the drift tube variants presented and evaluated here offer a low-cost alternative to commercial drift-tube systems with levels of performance that approach theoretical maxima.
随着离子迁移谱（IMS）应用范围的扩大和更多实验配置的开发，研究人员在为实验活动选择正确的平台时面临着更大的挑战。此外，用于比较性能的指标（例如）在不同平台之间的定义往往存在细微差异，这使得直接比较变得困难。在这里，我们比较了三个相对低成本且易于构建的 DIY 漂移管，根据三个不同的指标评估了每个漂移管的性能：分辨率、分辨率的理想度以及值的准确度/精密度。Reinecke 和 Clowers 开发的标准 PCBIMS 设计（Reinecke, T.; Clowers, B. H. 2018, 4, e00030）在三个系统中具有最高的分辨率（>90）和最高的分辨率理想度比值（最佳情况下>90%）。然而，Smith 等人描述的柔性管（FlexIMS）结构（Smith, B. L. 2020, 92 (13), 9104-9112）表现出值的最高精度（相对标准偏差<0.42%）。根据应用的不同，这里提出和评估的漂移管变体为具有接近理论最大值的性能的商业漂移管系统提供了一种低成本替代方案。
