Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Hum Cell. 2023 Sep;36(5):1604-1619. doi: 10.1007/s13577-023-00941-3. Epub 2023 Jul 5.
Women's infertility impacts the quality of life of both patients and couples and has multifaceted dimensions that increase the number of challenges associated with female infertility and how to face them. Female reproductive disorders, such as premature ovarian failure (POF), endometriosis, Asherman syndrome (AS), polycystic ovary syndrome (PCOS), and preeclampsia, can stimulate infertility. In the last decade, translational medicine has advanced, and scientists are focusing on infertility therapy with innovative attitudes. Recent investigations have suggested that stem cell treatments could be safe and effective. Stem cell therapy has established a novel method for treating women's infertility as part of a regeneration approach. The chief properties and potential of mesenchymal stem/stromal cells (MSCs) in the future of women's infertility should be considered by researchers. Due to their high abundance, great ability to self-renew, and high differentiation capacity, as well as less ethical concerns, MSC-based therapy has been found to be an effective alternative strategy to the previous methods for treating female infertility, such as intrauterine insemination, in vitro fertilization, medicines, and surgical procedures. These types of stem cells exert their beneficial role by releasing active mediators, promoting cell homing, and contributing to immune modulation. Here we first provide an overview of MSCs and their crucial roles in both biological and immunological processes. The next large chapter covers current preclinical and clinical studies on the application of MSCs to treat various female reproductive disorders. Finally, we deliberate on the extant challenges that hinder the application of MSCs in female infertility and suggest plausible measures to alleviate these impediments.
女性不孕影响患者和夫妇的生活质量，具有多方面的维度，增加了与女性不孕相关的挑战的数量以及如何面对这些挑战。女性生殖障碍，如卵巢早衰（POF）、子宫内膜异位症、Asherman 综合征（AS）、多囊卵巢综合征（PCOS）和子痫前期，会刺激不孕。在过去的十年中，转化医学取得了进展，科学家们正在以创新的态度关注不孕治疗。最近的研究表明，干细胞治疗可能是安全有效的。干细胞治疗作为再生方法的一部分，为治疗女性不孕开辟了新途径。研究人员应该考虑间充质干细胞/基质细胞（MSCs）在未来女性不孕治疗中的主要特性和潜力。由于其丰富的数量、强大的自我更新能力和高分化能力，以及较少的伦理问题，基于 MSC 的治疗已被发现是治疗女性不孕的先前方法（如宫腔内人工授精、体外受精、药物和手术）的有效替代策略。这些类型的干细胞通过释放活性介质、促进细胞归巢和有助于免疫调节来发挥其有益作用。在这里，我们首先概述了 MSCs 及其在生物学和免疫学过程中的关键作用。下一个大章节涵盖了 MSCs 应用于治疗各种女性生殖障碍的当前临床前和临床研究。最后，我们讨论了阻碍 MSCs 在女性不孕中的应用的现存挑战，并提出了缓解这些障碍的合理措施。
