The Laboratory of Cancer Precision Medicine, the First Hospital of Jilin University, Changchun, Jilin 130061, China.
The Laboratory of Cancer Precision Medicine, the First Hospital of Jilin University, Changchun, Jilin 130061, China; Department of Gynecologic Oncology, Gynecology and Obstetrics Centre, the First Hospital of Jilin University, Changchun, Jilin 130012, China.
Life Sci. 2023 Jun 1;322:121658. doi: 10.1016/j.lfs.2023.121658. Epub 2023 Apr 4.
Millions of women worldwide suffer from infertility associated with gynecologic disorders such as premature ovarian insufficiency, polycystic ovary syndrome, Asherman syndrome, endometriosis, preeclampsia, and fallopian tube obstruction. These disorders can lead to infertility and thereby affect the quality of life of the infertile couple because of their psychological impact and significant costs. In recent years, stem cell therapy has emerged as a therapeutic approach to repair or replace damaged tissues or organs. This review describes the recent development as well as the underlying mechanisms of stem cell therapy for a variety of female reproductive diseases, offering us new therapeutic options for the treatment of female reproductive and endocrine dysfunction.
全世界数以百万计的女性患有与妇科疾病相关的不孕症，例如卵巢早衰、多囊卵巢综合征、Asherman 综合征、子宫内膜异位症、子痫前期和输卵管阻塞。这些疾病会导致不孕，从而影响不孕夫妇的生活质量，因为它们会带来心理影响和巨大的经济负担。近年来，干细胞疗法已成为修复或替代受损组织或器官的治疗方法。本综述描述了干细胞疗法治疗各种女性生殖疾病的最新进展及其潜在机制，为治疗女性生殖和内分泌功能障碍提供了新的治疗选择。
