Rubinstein E, Knudsen J B
Ann Chir Gynaecol. 1986;75(3):177-9.
Second-look laparotomy was performed in 56 patients with ovarian cancer, who presented no clinical evidence of disease after completion of a treatment program with chemotherapy. At the second-look laparotomy 31 of the patients were found to have residual disease, and 25 patients had no residual tumour. During the second-look operations we found it difficult to evaluate macroscopically whether there was any residual disease. 21% of the patients were estimated as false negative and 6% as false positive. This stresses the importance of taking multiple biopsies in the absence of clearly visible residual disease confirmed by frozen sections.
对56例卵巢癌患者进行了二次剖腹探查术，这些患者在完成化疗治疗方案后无疾病的临床证据。在二次剖腹探查术中，发现31例患者有残留病灶，25例患者无残留肿瘤。在二次手术过程中，我们发现很难从宏观上评估是否存在任何残留病灶。估计21%的患者为假阴性，6%为假阳性。这强调了在没有经冰冻切片证实的明显可见残留病灶的情况下进行多次活检的重要性。
