Knee and Sport Medicine Research Center, Milad Hospital, Tehran, Iran.
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Med Case Rep. 2023 Jul 6;17(1):282. doi: 10.1186/s13256-023-04004-x.
Copenhagen syndrome (CS) is a rare disorder mostly observed in adolescent. The onset of the disease, with a progressive anterior vertebral ankylosis in the thoracic and/or lumbar areas often clinically revealed by thoracolumbar kyphosis. We report a series of three patients of CS with good outcome.
The mean age of patients were 14.0 (SD = 3.6) years at admission time. Patients underwent clinical and radiological examination (MRI, CT scan, and bone scan) before surgery and revealed Copenhagen syndrome. Case 2 received conservative treatment braces and regular follow-up. Finally, all patients were treated according to their clinical conditions through a combined surgical approach such as pedicle subtraction osteotomy (PSO), ponte osteotomy, hook, pedicular screw insertion, and fusion. In postoperative follow-up, the deformity correction was achieved with proper alignment in all the cases.
The treatment of CS with PSO plus ponte osteotomy seems to result in an excellent surgical procedure and outcome for our patients based on deformity severity. Bone scan imaging could be considered as an aid to differential diagnosis, which is an effective method.
哥本哈根综合征（CS）是一种罕见的疾病，主要发生在青少年。该病的发病机制为进行性胸腰椎前脊柱融合，通常临床上表现为胸腰椎后凸畸形。我们报告了三例 CS 患者的治疗结果良好。
患者平均年龄为 14.0 岁（标准差=3.6）。患者在手术前接受了临床和影像学检查（MRI、CT 扫描和骨扫描），结果显示为哥本哈根综合征。病例 2 接受了保守治疗支具和定期随访。最后，所有患者均根据其临床情况通过联合手术治疗，如椎弓根截骨术（PSO）、桥接截骨术、钩、椎弓根螺钉置入和融合。在术后随访中，所有患者的畸形均得到矫正，且排列适当。
根据畸形的严重程度，PSO 加桥接截骨术治疗 CS 似乎为我们的患者带来了极好的手术效果和预后。骨扫描成像可作为辅助鉴别诊断，是一种有效的方法。
