Department of Critical Care Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Institute of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Eur J Med Res. 2023 Jul 5;28(1):222. doi: 10.1186/s40001-023-01183-7.
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, with a high morbidity and mortality rate. Exogenous vitamin C supplementation is a potential therapeutic option for the treatment of multi-organ dysfunction in sepsis due to the significantly lower levels of vitamin C in the circulating blood of sepsis patients compared to healthy subjects and the importance of vitamin C in many of the physiological processes of sepsis. Vitamin C may influence the function of numerous organs and systems, including the heart, lungs, kidneys, brain, and immune defences, by reducing oxidative stress, inhibiting inflammatory factor surges, regulating the synthesis of various mediators and hormones, and enhancing immune cell function. With the development of multiple clinical randomized controlled trials, the outcomes of vitamin C treatment for critically ill patients have been discussed anew. This review's objectives are to provide an overview of how vitamin C affects various organ functions in sepsis and to illustrate how it affects each organ. Understanding the pharmacological mechanism of vitamin C and the organ damage caused by sepsis may help to clarify the conditions and clinical applications of vitamin C.
败血症是一种由宿主对感染的失调反应引起的危及生命的器官功能障碍，其发病率和死亡率都很高。外源性维生素 C 补充剂是治疗败血症多器官功能障碍的一种潜在治疗选择，因为败血症患者循环血液中的维生素 C 水平明显低于健康受试者，而且维生素 C 在败血症的许多生理过程中都很重要。维生素 C 可以通过降低氧化应激、抑制炎症因子的激增、调节各种介质和激素的合成以及增强免疫细胞功能，影响心脏、肺、肾、脑和免疫防御等众多器官和系统的功能。随着多项临床随机对照试验的开展，维生素 C 治疗危重症患者的疗效再次受到讨论。本综述的目的是概述维生素 C 如何影响败血症中各种器官的功能，并说明其对每个器官的影响。了解维生素 C 的药理学机制以及败血症引起的器官损伤，可能有助于阐明维生素 C 的适用条件和临床应用。
