Emergency Department and Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
J Tradit Chin Med. 2023 Oct;43(5):1040-1046. doi: 10.19852/j.cnki.jtcm.20230727.003.
TanshinoneⅡA (TanⅡA) is a noteworthy lipophilic diterpene compound derived from the dried roots of the Traditional Chinese Medicine Danshen () that has various pharmacological properties, including anti-inflammatory, antibacterial, and antioxidative effects. Sepsis is a life-threatening organ dysfunction induced by a dysregulated host response to infection. Recently, increasing attention has been paid to sepsis-induced dysfunction of the intestine, car-diovascular system, lungs, kidneys, liver, and other organs. Experimental studies have shown that TanⅡA has therapeutic potential for sepsis-induced organ dysfunction owing to its anti-inflammatory, anti-apoptotic and regulatory effects on multiple signalling pathways. The purpose of this article is to evaluate the potential multiorgan protective effects of TanⅡA in sepsis.
丹参酮ⅡA（TanⅡA）是一种源自丹参（）的脂溶性二萜化合物，具有多种药理学特性，包括抗炎、抗菌和抗氧化作用。败血症是一种由宿主对感染的失调反应引起的危及生命的器官功能障碍。最近，人们越来越关注败血症引起的肠道、心血管系统、肺、肾、肝和其他器官的功能障碍。实验研究表明，由于其对多种信号通路的抗炎、抗凋亡和调节作用，TanⅡA 对败血症引起的器官功能障碍具有治疗潜力。本文旨在评估 TanⅡA 在败血症中的多器官保护作用。
