Fantino M, Faion F, Rolland Y
Appetite. 1986;7 Suppl:115-26. doi: 10.1016/s0195-6663(86)80057-5.
The food hoarding behaviour paradigm (HB) was used to evaluate the modification of the set-point of body weight (BW) regulation induced by dexfenfluramine (D-FF) in rats fed with chow or previously made obese by a cafeteria diet for 51 days. Daily injections of D-FF at a dose of 7 mg/kg (i.p.) induced a 58.5 g shift-down of the BW set-point in a group of chow fed rats submitted to HB measurement, and induced an equivalent weight reducing effect in a control-BW group always fed with chow ad libitum. In the rats fed ad libitum with the cafeteria diet, the BW reducing effect of D-FF(7 mg/kg/day) was about twice as great as in the lean rats. The HB measurement indicates that the vehicle-injected/cafeteria-obese rats had a BW set-point 54.6 g lower than the BW they reached when fed ad libitum with the cafeteria diet. It was concluded that the hyperphagia induced by the cafeteria diet was above that needed for BW regulation, and that D-FF may suppress this unregulated weight increase. In the cafeteria-obese rats submitted to HB measurement and D-FF injections a BW set-point 110.7 g lower than their initial ad libitum BW was observed. It is concluded that D-FF has induced a double effect in these rats: (1) a shift-down of the BW set-point and (2) the suppression of the unregulated weight increase induced by the cafeteria diet.
食物囤积行为范式（HB）用于评估在喂食普通饲料的大鼠或先前通过自助餐饮食诱导肥胖51天的大鼠中，右芬氟拉明（D-FF）对体重（BW）调节设定点的改变。以7mg/kg（腹腔注射）的剂量每日注射D-FF，在一组接受HB测量的喂食普通饲料的大鼠中，导致体重设定点向下偏移58.5g，并且在始终自由进食普通饲料的对照体重组中诱导出同等的体重减轻效果。在自由进食自助餐饮食的大鼠中，D-FF（7mg/kg/天）的体重减轻效果约为瘦大鼠的两倍。HB测量表明，注射赋形剂/自助餐诱导肥胖的大鼠的体重设定点比它们自由进食自助餐饮食时达到的体重低54.6g。得出的结论是，自助餐饮食诱导的食欲亢进高于体重调节所需的水平，并且D-FF可能抑制这种不受调节的体重增加。在接受HB测量和D-FF注射的自助餐诱导肥胖的大鼠中，观察到体重设定点比它们最初的自由进食体重低110.7g。得出的结论是，D-FF在这些大鼠中产生了双重作用：（1）体重设定点向下偏移；（2）抑制自助餐饮食诱导的不受调节的体重增加。
