Rozen R, Fumeron F, Betoulle D, Baigts F, Mandenoff A, Fricker J, Apfelbaum M
Nutrition Humaine-Bichat Medical School, Paris, France.
Clin Neuropharmacol. 1988;11 Suppl 1:S105-12.
In order to test the hypothesis of Levitzky that d-fenfluramine (d-F) acts by modifying the ponderal set-point, we compared the effects of a permanent infusion of d-F on food intake and body weight (BW). The effect on the weight persisted as long as the infusion; the clear-cut anorectic effect lasted only a few days. This paradox is compatible with the set-point hypothesis. In rats rendered overweight by insulin treatment, the d-F-induced decrease in BW was approximately four times smaller than in controls. In rats rendered overweight by a cafeteria diet, the decrease in BW was twice as large in permanently cafeteria fed rats as in cafeteria, then, ad lib fed rats. In rats rendered underweight by a restricted chow diet and then returned to an ad lib feeding, the final BW depended only on the doses of d-F (0.6 or 12 mg/kg BW/day), whatever the weight at the beginning of infusion. Thus, the underweight paradigm fits well with the set-point hypothesis; the overweight paradigm fits only partially.
为了验证列维茨基的假说，即右旋芬氟拉明（d-F）通过改变体重调节点起作用，我们比较了持续输注d-F对食物摄入量和体重（BW）的影响。只要持续输注，对体重的影响就会持续；明显的厌食作用仅持续几天。这种矛盾现象与体重调节点假说相符。在用胰岛素治疗使大鼠超重的情况下，d-F引起的体重下降比对照组小约四倍。在用自助餐饮食使大鼠超重的情况下，长期食用自助餐的大鼠体重下降幅度是先食用自助餐然后随意进食的大鼠的两倍。在用限制饲料喂养使大鼠体重过轻然后恢复随意进食的情况下，最终体重仅取决于d-F的剂量（0.6或12毫克/千克体重/天），无论输注开始时的体重如何。因此，体重过轻的模式与体重调节点假说非常吻合；超重模式仅部分吻合。
