Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.
Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan, India.
J Cell Biochem. 2023 Jul;124(7):923-942. doi: 10.1002/jcb.30433. Epub 2023 Jul 6.
Akt, a known serine/threonine-protein kinase B has been revealed to be an imperative protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3. Ubiquitously expressed Akt1 & Akt2 are essential for cell survival and are believed to be involved in regulating glucose homeostasis. PI3K/Akt pathway has been evidenced to be associated with metabolic diseases viz. hypertension, dyslipidemia, and diabetes. Akt interacting proteins have been revealed to be scaffold proteins of the PI3K/Akt pathway. Notably, some protein-protein interactions are imperative for the inhibition or uncontrolled activation of these signaling pathways. For instance, Akt interacting protein binds with other protein namely, FOXO1 and mTOR, and play a key role in the onset and progression of metabolic syndrome (MS). The purpose of this review is to highlight the role of the PI3K/Akt pathway and associated protein-protein interactions which might serve as a valuable tool for investigators to develop some new promising therapeutic agents in the management of MS.
Akt，一种已知的丝氨酸/苏氨酸蛋白激酶 B，已被揭示为 PI3K/Akt 通路的重要蛋白。Akt 有三种同工型，即 Akt1、Akt2 和 Akt3。普遍表达的 Akt1 和 Akt2 对细胞存活至关重要，据信它们参与调节葡萄糖稳态。PI3K/Akt 通路与代谢疾病（如高血压、血脂异常和糖尿病）有关。已经揭示 Akt 相互作用蛋白是 PI3K/Akt 通路的支架蛋白。值得注意的是，一些蛋白-蛋白相互作用对于这些信号通路的抑制或不受控制的激活是必不可少的。例如，Akt 相互作用蛋白与其他蛋白（即 FOXO1 和 mTOR）结合，并在代谢综合征 (MS) 的发生和进展中发挥关键作用。本综述的目的是强调 PI3K/Akt 通路及其相关蛋白-蛋白相互作用的作用，这可能为研究人员提供有价值的工具，以开发一些新的有前途的治疗代谢综合征的药物。
