Chinese PLA Medical School, Beijing 100853, China.
Department of Critical Care Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.
J Zhejiang Univ Sci B. 2024 Sep 15;25(9):723-735. doi: 10.1631/jzus.B2300886.
Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary society. Addressing these concerns is an imperative task, with the aims of postponing the aging process and finding effective treatments for age-related degenerative diseases. Recent investigations have highlighted the significant roles of nicotinamide adenine dinucleotide (NAD) in the realm of anti-aging. It has been empirically evidenced that supplementation with nicotinamide mononucleotide (NMN) can elevate NAD levels in the body, thereby ameliorating certain age-related degenerative diseases. The principal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism, inhibition of cell apoptosis, modulation of immune function, and preservation of genomic stability, which collectively contribute to the deferral of the aging process. This paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN, elucidates the inherent limitations of current research, and proposes novel avenues for anti-aging investigations.
衰老是全球当代社会面临的关键挑战和巨大负担。应对这些问题是当务之急，目标是延缓衰老过程和寻找针对与年龄相关的退行性疾病的有效治疗方法。最近的研究强调了烟酰胺腺嘌呤二核苷酸 (NAD) 在抗衰老领域的重要作用。经验证据表明，补充烟酰胺单核苷酸 (NMN) 可以提高体内 NAD 水平，从而改善某些与年龄相关的退行性疾病。NMN 的主要抗衰老机制主要在于其对细胞能量代谢的影响、抑制细胞凋亡、调节免疫功能和维持基因组稳定性，这些共同作用延缓了衰老过程。本文批判性地回顾和评估了 NMN 的抗衰老机制的现有研究，阐明了当前研究的固有局限性，并为抗衰老研究提出了新的途径。
