Department of Special Surgery / Opthalmology Division, University of Jordan, Amman, Jordan.
Independent Researcher Lanceshire UK.
Middle East Afr J Ophthalmol. 2023 May 25;29(3):116-121. doi: 10.4103/meajo.meajo_135_22. eCollection 2022 Jul-Sep.
To determine the effect of smoking on the response to anti-vascular endothelial growth factor (anti-VEGF) therapy treatment in patients with diabetic macular edema (DME).
This is a retrospective case - control study that included 60 eyes with DME. Smoking habits were obtained from hospital records and patient recall. Patients were divided into two groups: the ever-smoker group and the never-smoker group. All patients received Intravitreal ranibizumab with three loading doses followed by PRN protocol and all were followed up for at least 1 year. Outcome measures were best-corrected visual acuity (BCVA), central retinal thickness (CRT) at the fovea, and number of visits.
Smoking was not associated with worse posttreatment visual acuity and was not found to influence the change in ocular coherence tomography measurement of central macular thickness and the change in BCVA (posttreatment minus pretreatment). There were no statistically significant differences in the duration of treatment or number of visits between two groups of patients the ever-smoker group and the never-smoker group ( > 0.05).
In this study, smoking status did not influence the treatment outcome of anti-VEGFs; however, smoking should be encouraged due to its well-known other systemic unwanted effects.
探讨吸烟对糖尿病黄斑水肿（DME）患者接受抗血管内皮生长因子（anti-VEGF）治疗反应的影响。
这是一项回顾性病例对照研究，纳入 60 只患 DME 的眼。吸烟习惯通过医院记录和患者回忆获得。患者分为两组：曾吸烟者组和从不吸烟者组。所有患者均接受玻璃体腔内雷珠单抗治疗，给予三次负荷剂量，然后采用 PRN 方案，所有患者均至少随访 1 年。观察指标包括最佳矫正视力（BCVA）、黄斑中心凹视网膜厚度（CRT）和就诊次数。
吸烟与治疗后视力下降无关，也不影响眼相干断层扫描测量的中心黄斑厚度的变化和 BCVA 的变化（治疗后减去治疗前）。曾吸烟者组和从不吸烟者组之间，治疗持续时间和就诊次数无统计学差异（>0.05）。
在这项研究中，吸烟状况并不影响抗 VEGFs 的治疗效果；然而，吸烟会导致已知的其他全身不良影响，应鼓励戒烟。
