Okeke Chidubem A V, Khanna Ramona, Ehrlich Alison
Department of Dermatology, Howard University College of Medicine, Washington, DC, USA.
Georgetown University School of Medicine, Washington, DC, USA.
Clin Cosmet Investig Dermatol. 2023 Jun 30;16:1721-1728. doi: 10.2147/CCID.S410910. eCollection 2023.
The recent global pandemic has resulted in increased use of quaternary ammonium compounds (QACs). Currently, QACs are active ingredients in 292 disinfectants recommended by the US EPA for use against SARS-CoV-2. Among QACs, benzalkonium chloride (BAK), cetrimonium bromide (CTAB), cetrimonium chloride (CTAC), didecyldimethylammonium chloride (DDAC), cetrimide, quaternium-15, cetylpyridinium chloride (CPC), and benzethonium chloride (BEC) were all identified as potential culprits of skin sensitivity. Given their widespread utilization, additional research is needed to better classify their dermal effects and identify other cross-reactors. In this review, we aimed to expand our knowledge about these QACs to further dissect its potential allergic and irritant dermal effects on healthcare workers during COVID-19.
近期的全球大流行导致季铵化合物（QACs）的使用增加。目前，QACs是美国环境保护局（EPA）推荐用于对抗SARS-CoV-2的292种消毒剂的活性成分。在QACs中，苯扎氯铵（BAK）、西曲溴铵（CTAB）、西曲氯铵（CTAC）、二癸基二甲基氯化铵（DDAC）、西曲碘铵、季铵盐-15、十六烷基吡啶氯化物（CPC）和苄索氯铵（BEC）均被确定为皮肤敏感的潜在诱因。鉴于它们的广泛使用，需要进行更多研究以更好地分类其对皮肤的影响并识别其他交叉反应物质。在本综述中，我们旨在扩展我们对这些QACs的认识，以进一步剖析其在COVID-19期间对医护人员潜在的过敏性和刺激性皮肤影响。
