Lee Sung-Bum, Kim Miryung, Lee Hui-Jeong, Kim Jong-Koo
Department of Family Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
Department of Medicine, Graduate School, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Front Med (Lausanne). 2023 Jun 20;10:1148386. doi: 10.3389/fmed.2023.1148386. eCollection 2023.
Handgrip strength (HGS) is an indicator of many diseases such as pneumonia, cardiovascular disease and cancer. HGS can also predict renal function in chronic kidney disease (CKD) patients, but the value of HGS as a predictor of new-onset CKD is unknown.
173,195 subjects were recruited from a nationwide cohort and were followed for 4.1 years. After exclusions, 35,757 participants remained in the final study, and CKD developed in 1063 individuals during the follow-up period. Lifestyle, anthropometric and laboratory data were evaluated in relation to the risk of CKD.
The participants were subdivided into quartiles according to relative handgrip strength (RGS). Multivariate Cox regression demonstrated that RGS was inversely associated with incident CKD. Compared with the lowest quartile, the hazard ratios (HRs) [95% confidence intervals (CIs)] for incident CKD for the highest quartile (Q4) was 0.55 (0.34-0.88) after adjusting for covariates in men and 0.51 (0.31-0.85) in women. The incidence of CKD decreased as RGS increased. These negative associations were more significant in men than in women. The receiver operating characteristic (ROC) curve showed that baseline RGS had predictive power for new-onset CKD. Area under the curve (AUC) (95% CIs) was 0.739 (0.707-0.770) in men and 0.765 (0.729-0.801) in women.
This is the novel study demonstrating that RGS is associated with incident CKD in both men and women. The relationship between RGS and incident CKD is more significant in women than in men. RGS can be used in clinical practice to evaluate renal prognosis. Regular measurement of handgrip strength is essential to CKD detection.
握力（HGS）是许多疾病的一个指标，如肺炎、心血管疾病和癌症。握力还可以预测慢性肾脏病（CKD）患者的肾功能，但握力作为新发CKD预测指标的价值尚不清楚。
从全国性队列中招募了173195名受试者，并随访4.1年。排除后，最终研究中保留了35757名参与者，随访期间有1063人发生CKD。对生活方式、人体测量和实验室数据与CKD风险的关系进行了评估。
根据相对握力（RGS）将参与者分为四分位数。多变量Cox回归表明，RGS与CKD的发生呈负相关。与最低四分位数相比，在调整协变量后，男性最高四分位数（Q4）发生CKD的风险比（HRs）[95%置信区间（CIs）]为0.55（0.34 - 0.88），女性为0.51（0.31 - 0.85）。CKD的发病率随着RGS的增加而降低。这些负相关在男性中比在女性中更显著。受试者工作特征（ROC）曲线显示，基线RGS对新发CKD具有预测能力。曲线下面积（AUC）（95% CIs）男性为0.739（0.707 - 0.770），女性为0.765（0.729 - 0.801）。
这项新研究表明，RGS与男性和女性的CKD发生均有关。RGS与CKD发生之间的关系在女性中比在男性中更显著。RGS可用于临床实践中评估肾脏预后。定期测量握力对CKD检测至关重要。
