Torabi Jahromi Mahsa, Roozbeh Jamshid, Masjedi Fatemeh, Mohammadzadeh Sahand, Tabei Seyed Sajjad, Shafiee Maryam, Rasaei Nakisa
Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pathology, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran.
Front Med (Lausanne). 2023 Jun 20;10:1092815. doi: 10.3389/fmed.2023.1092815. eCollection 2023.
A rare case of a 35 years old woman presented with renal arcuate vein thrombosis (RAVT) and acute kidney injury (AKI) following upper respiratory tract symptoms and toxic substance ingestion. Histopathological evaluation of the patient's kidney tissue indicated a rare venous thrombosis in the renal arcuate veins. Anticoagulation with Apixaban, a direct oral anticoagulant (DOAC), was commenced, and the patient's symptoms resolved during the hospital stay. Hitherto, a limited number of studies have shown the concurrent presentation of RAVT and overt AKI in patients following ingestion of nephrotoxic agents. Further studies are necessary to elucidate the etiology, clinical presentation, and treatment of RAVT. We suggest that Apixaban be studied as a suitable alternative to conventionally used anti-coagulants such as Warfarin in patients who lack access to optimal health care facilities.
一名35岁女性的罕见病例,在上呼吸道症状和摄入有毒物质后出现肾弓状静脉血栓形成(RAVT)和急性肾损伤(AKI)。对患者肾组织的组织病理学评估显示肾弓状静脉存在罕见的静脉血栓形成。开始使用直接口服抗凝剂(DOAC)阿哌沙班进行抗凝治疗,患者的症状在住院期间得到缓解。迄今为止,有限的研究表明,摄入肾毒性药物的患者同时出现RAVT和明显的AKI。需要进一步研究以阐明RAVT的病因、临床表现和治疗方法。我们建议,对于无法获得最佳医疗保健设施的患者,应研究阿哌沙班作为传统使用的抗凝剂(如华法林)的合适替代品。