Isık Ümit, Kılıç Faruk, Demirdas Arif, Aktepe Evrim, Aydogan Avsar Pınar
Department of Child and Adolescent Psychiatry, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey.
Department of Psychiatry, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey.
Psychiatry Investig. 2020 Mar;17(3):256-261. doi: 10.30773/pi.2019.0247. Epub 2020 Mar 11.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with underlying pathogenesis and etiological factors not fully understood. We assumed that galectin-3, which is also linked with inflammatory responses, may play an important role in the ethiopathogenesis of ADHD. In this study, we aimed to investigate whether serum galectin-3 levels are related to ADHD in childhood.
The current study consisted of 35 treatment-naive children with ADHD and 35 control subjects. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires. The severity of anxiety and depression symptoms of the children were determined by the self-report scale. Venous blood samples were collected and serum galectin-3 levels were measured.
The ADHD group had significantly higher serum Galectin-3 levels than the control group. To control confounding factors, including age, sex, and BMI percentile, one-way analysis of covariance (ANCOVA) test was also performed. Analyses revealed a significantly higher serum log- Galectin-3 levels in children with ADHD compared to controls. No association was found between the mean serum galectin-3 levels and sociodemographic characteristics and clinical test scores, except the oppositional defiant behavior scores.
Our research supports the hypothesis that serum levels of galectin-3 might be related to ADHD.
注意力缺陷多动障碍（ADHD）是一种神经发育障碍，其潜在的发病机制和病因尚未完全明确。我们推测，同样与炎症反应相关的半乳糖凝集素-3可能在ADHD的发病机制中起重要作用。在本研究中，我们旨在调查儿童血清半乳糖凝集素-3水平是否与ADHD有关。
本研究包括35名未经治疗的ADHD儿童和35名对照受试者。通过家长和教师评定问卷评估ADHD和品行障碍症状的严重程度。通过自我报告量表确定儿童焦虑和抑郁症状的严重程度。采集静脉血样本并测量血清半乳糖凝集素-3水平。
ADHD组血清半乳糖凝集素-3水平显著高于对照组。为控制包括年龄、性别和BMI百分位数在内的混杂因素，还进行了单因素协方差分析（ANCOVA）测试。分析显示，与对照组相比，ADHD儿童的血清对数半乳糖凝集素-3水平显著更高。除对立违抗行为得分外，未发现血清半乳糖凝集素-3平均水平与社会人口学特征和临床测试得分之间存在关联。
我们的研究支持血清半乳糖凝集素-3水平可能与ADHD有关的假设。
