Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, P.R. China.
Faculty of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, P.R. China.
Expert Rev Mol Diagn. 2023 Jul-Dec;23(7):583-588. doi: 10.1080/14737159.2023.2223981. Epub 2023 Jul 6.
Due to the limited number of studies focusing on the optimal treatment of multiple Krukenberg tumor (KT)-gastric carcinoma (KT - GC), it is necessary to conduct large-scale studies to confirm the definite role of serum tumor markers in the diagnosis and prognosis of KT. Moreover, the clinical significance of variant 6 of CD44 (CD44v6) in transcoelomic metastasis should be considered.
This review covers molecular pre-cancer diagnosis, gastric carcinoma metastasis, and anti-cancer treatments. Additionally, gastrointestinal cancer metastasis is a key area for improvement.
The detection of CD44v6 differs in the World Health Organization Classification of Gastric Adenocarcinoma, the Lauren Classification of Gastric Adenocarcinoma, and the anatomic location of gastric adenocarcinoma. The results were compared among the three groups. The mechanism of gastric adenocarcinoma metastasis still requires further elucidation. CD44v6 molecular detection helps clarify the pre-cancer diagnosis of KT before seeding. If subsequent studies confirm its role as a signaling molecule, it could pave the way for new research directions in clinical practice; however, additional academic confirmation is necessary.
由于针对多发克鲁根伯格瘤（KT）-胃癌（KT-GC）的最佳治疗方法的研究数量有限，有必要开展大规模研究来确认血清肿瘤标志物在 KT 诊断和预后中的明确作用。此外，还应考虑 CD44 变体 6（CD44v6）在体腔转移中的临床意义。
本综述涵盖了分子癌前诊断、胃癌转移和抗癌治疗，此外，胃肠道癌转移是一个需要改进的关键领域。
CD44v6 的检测在世界卫生组织胃癌分类、胃腺癌劳伦分类和胃腺癌解剖位置中存在差异。将三组的结果进行了比较。胃腺癌转移的机制仍需进一步阐明。CD44v6 分子检测有助于阐明播种前 KT 的癌前诊断。如果后续研究证实其作为信号分子的作用，可能为临床实践中的新研究方向铺平道路；然而，还需要更多的学术确认。
