改良电抽搐治疗对精神分裂症的临床效果。

Clinical effect of modified electroconvulsive therapy on schizophrenia.

机构信息

Operating Room, Wuhan Wudong Hospital (Wuhan Second Psychiatric Hospital), Wuhan, China.

Department of Psychiatry, Wuhan Wudong Hospital (Wuhan Second Psychiatric Hospital), Wuhan, China.

出版信息

Riv Psichiatr. 2023 Jul-Aug;58(4):183-189. doi: 10.1708/4064.40481.

DOI:10.1708/4064.40481

PMID:37409436

Abstract

OBJECTIVE

To investigate the clinical efficacy of modified electroconvulsive therapy (MECT) in patients with schizophrenia and provide a reference for the selection of safe and effective treatment options in clinical practice.

METHODS

A total of 200 patients with schizophrenia, who were admitted to Wuhan Wudong Hospital Psychiatric Hospital from January 2019 to December 2020, were selected as the study subjects. They were divided into an observation group and a control group (100 cases in each group) according to a random number table. The control group was treated with conventional antipsychotics (risperidone and aripiprazole), and the observation group was given conventional antipsychotics (risperidone and aripiprazole) with MECT. After 8 weeks, the clinical efficacy, cognitive and memory functions and the occurrence of adverse reactions between the two groups were compared.

RESULTS

The total clinical effective rate of the observation group was 90%, which was higher than that of the control group (74%), and the difference was statistically significant (p<0.05). The Wisconsin Card Sorting Test results of the observation group were better than those of the control group, and the cognitive function of the observation group was better than that of the control group (p<0.05). The Wechsler Adult Intelligence Scale-Fourth Edition index of the observation group was higher than that of the control group, and the memory function of the observation group was better than that of the control group (p<0.05). The overall incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (p=0.001).

CONCLUSION

The application of MECT in patients with schizophrenia can produce a good clinical curative effect, which is beneficial to the improvement and promotion of memory and cognitive functions in patients. Since the occurrence of adverse reactions is controllable, and safety is ideal, MECT has value in clinical application.

摘要

目的

探讨改良电抽搐治疗（MECT）对精神分裂症患者的临床疗效，为临床实践中安全有效治疗方案的选择提供参考。

方法

选取 2019 年 1 月至 2020 年 12 月期间于武汉武东医院精神科住院的 200 例精神分裂症患者作为研究对象，采用随机数字表法将其分为观察组和对照组（各 100 例）。对照组采用常规抗精神病药物（利培酮、阿立哌唑）治疗，观察组在对照组治疗基础上给予改良电抽搐治疗。治疗 8 周后，比较两组的临床疗效、认知和记忆功能及不良反应发生情况。

结果

观察组总有效率为 90%，高于对照组的 74%，差异有统计学意义（p<0.05）。观察组威斯康星卡片分类测验结果优于对照组，认知功能优于对照组（p<0.05）。观察组韦氏成人智力量表第四版指数高于对照组，记忆功能优于对照组（p<0.05）。观察组不良反应总发生率低于对照组，差异有统计学意义（p=0.001）。