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Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults.

作者信息

Guarischi-Sousa Rodrigo, Salfati Elias, Kho Pik Fang, Iyer Kruthika R, Hilliard Austin T, Herrington David M, Tsao Philip S, Clarke Shoa L, Assimes Themistocles L

机构信息

Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).

Scripps Research Translational Institute at Scripps Research, La Jolla, CA (E.S.).

出版信息

Circ Genom Precis Med. 2023 Oct;16(5):480-482. doi: 10.1161/CIRCGEN.122.004047. Epub 2023 Jul 6.

DOI:10.1161/CIRCGEN.122.004047
PMID:37409455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10581412/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82ce/10581412/2b65c6ffeb31/hcg-16-480-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82ce/10581412/2b65c6ffeb31/hcg-16-480-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82ce/10581412/2b65c6ffeb31/hcg-16-480-g001.jpg

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本文引用的文献

1
The power of genetic diversity in genome-wide association studies of lipids.遗传多样性在全基因组关联研究脂质中的作用。
Nature. 2021 Dec;600(7890):675-679. doi: 10.1038/s41586-021-04064-3. Epub 2021 Dec 9.
2
The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation.多基因风险评分目录作为一个开放的数据库，用于可重复性和系统评估。
Nat Genet. 2021 Apr;53(4):420-425. doi: 10.1038/s41588-021-00783-5.
3
Polygenic Risk Score for Low-Density Lipoprotein Cholesterol Is Associated With Risk of Ischemic Heart Disease and Enriches for Individuals With Familial Hypercholesterolemia.
一个在日本验证的心血管风险模型应用于意大利队列：谨慎行事。
J Nucl Cardiol. 2023 Aug;30(4):1454-1457. doi: 10.1007/s12350-023-03242-2. Epub 2023 Mar 22.
载脂蛋白 B 与低密度脂蛋白胆固醇的多基因风险评分与缺血性心脏病风险相关，并与家族性高胆固醇血症患者重叠。
Circ Genom Precis Med. 2021 Feb;14(1):e003106. doi: 10.1161/CIRCGEN.120.003106. Epub 2021 Jan 13.
4
Susceptibility Loci for Clinical Coronary Artery Disease and Subclinical Coronary Atherosclerosis Throughout the Life-Course.临床冠心病和终生亚临床冠状动脉粥样硬化的易感基因座。
Circ Cardiovasc Genet. 2015 Dec;8(6):803-11. doi: 10.1161/CIRCGENETICS.114.001071. Epub 2015 Sep 28.
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Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study.青少年和青年动脉粥样硬化的患病率及程度：来自青年动脉粥样硬化病理生物学决定因素研究的预防启示
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