College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Guangdong Ocean University, Zhanjiang, China.
Crit Rev Food Sci Nutr. 2024;64(30):10987-11005. doi: 10.1080/10408398.2023.2230501. Epub 2023 Jul 6.
Diet can be considered as one of the pivotal factors in regulating gastrointestinal health, and polyphenols widely distributed in human daily diet. The polyphenols and their metabolites playing a series of beneficial effects in human gastrointestinal tract that can regulate of the gut microbiota, increase intestinal barrier function, repair gastrointestinal mucosa, reduce oxidative stress, inhibit the secretion of inflammatory factors and regulating immune function, and their absorption and biotransformation mainly depend on the activity of intestinal microflora. However, little is known about the two-way interaction between polyphenols and intestinal microbiota. The objective of this review is to highlight the structure optimization and effect of flavonoids on intestinal flora, and discusses the mechanisms of dietary flavonoids regulating intestinal flora. The multiple effects of single molecule of flavonoids, and inter-dependence between the gut microbiota and polyphenol metabolites. Moreover, the protective effects of polyphenols on intestinal barrier function, and effects of interaction between plant polyphenols and macromolecules on gastrointestinal health. This review provided valuable insight that may be useful for better understanding the mechanism of the gastrointestinal health effects of polyphenols, and provide a scientific basis for their application as functional food.
饮食被认为是调节胃肠道健康的关键因素之一，而多酚广泛存在于人类日常饮食中。多酚及其代谢产物在人体胃肠道中发挥一系列有益作用，可调节肠道菌群、增加肠道屏障功能、修复胃肠道黏膜、减轻氧化应激、抑制炎症因子分泌和调节免疫功能，其吸收和生物转化主要依赖于肠道菌群的活性。然而，多酚与肠道菌群之间的双向相互作用知之甚少。本综述的目的是强调类黄酮对肠道菌群的结构优化和作用，并讨论膳食类黄酮调节肠道菌群的机制。单一分子类黄酮的多种作用，以及肠道菌群和多酚代谢物之间的相互依存关系。此外，还探讨了多酚对肠道屏障功能的保护作用，以及植物多酚与大分子相互作用对胃肠道健康的影响。本综述提供了有价值的见解，可能有助于更好地理解多酚对胃肠道健康影响的机制，并为其作为功能性食品的应用提供科学依据。
