Department of Food Science and Engineering, Ningbo University, Ningbo, People's Republic of China.
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
J Sci Food Agric. 2023 Jan 30;103(2):488-495. doi: 10.1002/jsfa.12151. Epub 2022 Aug 15.
The chances of people suffering from cognitive impairments increase gradually with age. Diet and lifestyle are closely related to the occurrence and development of cognitive function. Dietary flavonoid supplementation has been shown to be one of the protective factors against cognitive decline. Flavonoids belong to a class of polyphenols that have been proposed for the treatment of cognitive decline. Recent evidence has shown that intestinal flora in the human body can interact with flavonoids. Intestinal microbiota can modify the chemical structure of flavonoids, producing new metabolites, the pharmacological activities of which may be different from those of the parent; meanwhile, flavonoids and their metabolites can, in turn, regulate the composition and structure of intestinal flora. Notably, intestinal flora affect host nervous system activity through the gut-brain axis, ultimately causing changes in cognitive function. This review therefore summarizes the interaction of dietary flavonoids and intestinal flora, and their protective effect against cognitive decline through the gut-brain axis, indicating that dietary flavonoids may ameliorate cognitive impairment through their interaction with intestinal microbiota. © 2022 Society of Chemical Industry.
随着年龄的增长，人们患认知障碍的几率逐渐增加。饮食和生活方式与认知功能的发生和发展密切相关。饮食中黄酮类化合物的补充已被证明是预防认知能力下降的保护因素之一。黄酮类化合物属于多酚类的一种，已被提议用于治疗认知能力下降。最近的证据表明，人体内的肠道菌群可以与黄酮类化合物相互作用。肠道微生物可以修饰黄酮类化合物的化学结构，产生新的代谢物，其药理活性可能与母体不同；同时，黄酮类化合物及其代谢物也可以反过来调节肠道菌群的组成和结构。值得注意的是，肠道菌群通过肠-脑轴影响宿主神经系统活动，最终导致认知功能的改变。因此，本综述总结了饮食黄酮类化合物与肠道菌群的相互作用，以及它们通过肠-脑轴对认知能力下降的保护作用，表明饮食黄酮类化合物可能通过与肠道微生物群的相互作用来改善认知障碍。© 2022 英国化学学会。
