Department of Otorhinolaryngology/Head and Neck Surgery, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
Department of Otorhinolaryngology/Head and Neck Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Laryngoscope. 2024 Feb;134(2):562-568. doi: 10.1002/lary.30865. Epub 2023 Jul 6.
The histological findings of wound healing depending on different nasal packing materials and replacement periods were lacking.
Mucosal defects were created in the nasal septum of rabbits and covered with Spongel®, Algoderm®, or Nasopore®, which were cleaned on Day 14. To investigate the effect of replacement durations, Spongel® was removed on Days 3 and 7. All nasal septal specimens were collected on Day 28. Samples without packing material were prepared as controls. Depending on residual packing materials in the regenerated tissue, specimens were classified into the remnant and non-remnant groups, and morphology was compared using epithelium grade score and subepithelial thickness.
The epithelium grade score in the Spongel-14d group was lower than that in the other groups (p < 0.05). Subepithelial thickness was higher in the Algoderm-14d and Spongel-14d groups (p < 0.05). Epithelium grade scores were higher and subepithelial thicknesses were lower in the Spongel-3d and -7d groups than in the Spongel-14d group. Epithelium grade score was lower and subepithelial thickness was higher in the remnant group (n = 10) than in the non-remnant group (n = 15; p < 0.05).
Differences in packing materials and placement durations affected wound healing of nasal mucosa. The selection of appropriate packing materials and replacement duration was considered essential for ideal wound healing.
NA Laryngoscope, 134:562-568, 2024.
不同的鼻腔填塞材料和更换时间对伤口愈合的组织学影响尚不清楚。
在兔鼻中隔上造成黏膜缺损，并用 Spongel®、Algoderm®或 Nasopore®覆盖，分别于第 14 天清除填塞物。为了研究更换时间的影响，Spongel®在第 3 天和第 7 天被移除。所有鼻中隔标本均于第 28 天收集。无填塞物的标本作为对照。根据再生组织中残留的填塞物，标本分为残留组和非残留组，通过上皮分级评分和黏膜下厚度比较形态。
Spongel-14d 组的上皮分级评分低于其他组（p<0.05）。Algoderm-14d 和 Spongel-14d 组的黏膜下厚度较高（p<0.05）。Spongel-3d 和 -7d 组的上皮分级评分较高，黏膜下厚度较低，而 Spongel-14d 组则较低。残留组（n=10）的上皮分级评分低于非残留组（n=15；p<0.05），而黏膜下厚度则较高。
填塞材料和放置时间的差异影响了鼻腔黏膜的愈合。选择合适的填塞材料和更换时间对于理想的伤口愈合至关重要。
无。《喉镜》，134：562-568，2024。
