通过两个英国队列中的饮食行为对肥胖遗传风险的中介和调节作用。

Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.

机构信息

Department of Psychology, College of Life and Environmental Sciences, University of Exeter, Exeter, UK.

NIHR Bristol BRC Nutrition Theme, University Hospitals Bristol Education & Research Centre, University of Bristol, Bristol, UK.

出版信息

Int J Epidemiol. 2023 Dec 25;52(6):1926-1938. doi: 10.1093/ije/dyad092.

DOI:10.1093/ije/dyad092

PMID:37410385

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10749755/

Abstract

BACKGROUND

The mechanisms underlying genetic predisposition to higher body mass index (BMI) remain unclear.

METHODS

We hypothesized that the relationship between BMI-genetic risk score (BMI-GRS) and BMI was mediated via disinhibition, emotional eating and hunger, and moderated by flexible (but not rigid) restraint within two UK cohorts: the Genetics of Appetite Study (GATE) (n = 2101, 2010-16) and the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 1679, 2014-18). Eating behaviour was measured by the Adult Eating Behaviour Questionnaire and Three-Factor Eating Questionaire-51.

RESULTS

The association between BMI-GRS and BMI were partially mediated by habitual, emotional and situational disinhibition in the GATE/ALSPAC meta-mediation [standardized betaindirect 0.04, 95% confidence interval (CI) 0.02-0.06; 0.03, 0.01-0.04; 0.03, 0.01-0.04, respectively] external hunger and internal hunger in the GATE study (0.02, 0.01-0.03; 0.01, 0.001-0.02, respectively). There was evidence of mediation by emotional over/undereating and hunger in the ALSPAC study (0.02, 0.01-0.03; 0.01, 0.001-0.02; 0.01, 0.002-0.01, respectively). Rigid or flexible restraint did not moderate the direct association between BMI-GRS and BMI, but high flexible restraint moderated the effect of disinhibition subscales on BMI (reduction of the indirect mediation by -5% to -11% in GATE/ALSPAC) and external hunger (-5%) in GATE. High rigid restraint reduced the mediation via disinhibition subscales in GATE/ALSPAC (-4% to -11%) and external hunger (-3%) in GATE.

CONCLUSIONS

Genetic predisposition to a higher BMI was partly explained by disinhibition and hunger in two large cohorts. Flexible/rigid restraint may play an important role in moderating the impact of predisposition to higher BMI.

摘要

背景

遗传易感性导致更高体重指数（BMI）的机制仍不清楚。

方法

我们假设 BMI-遗传风险评分（BMI-GRS）与 BMI 之间的关系通过抑制、情绪化进食和饥饿来介导，并在两个英国队列中得到调节：食欲研究的遗传学（GATE）（n=2101，2010-16）和雅芳纵向父母和儿童研究（ALSPAC）（n=1679，2014-18）。饮食行为通过成人饮食行为问卷和三因素饮食问卷-51 进行测量。

结果

在 GATE/ALSPAC 元中介分析中，BMI-GRS 与 BMI 之间的关联部分通过习惯性、情绪性和情境性抑制来介导[标准化贝塔间接 0.04，95%置信区间（CI）0.02-0.06；0.03，0.01-0.04；0.03，0.01-0.04，分别]在 GATE 研究中，外部饥饿和内部饥饿（0.02，0.01-0.03；0.01，0.001-0.02，分别）。在 ALSPAC 研究中，有情绪过度/不足进食和饥饿的中介证据（0.02，0.01-0.03；0.01，0.001-0.02；0.01，0.002-0.01，分别）。刚性或柔性约束并没有调节 BMI-GRS 与 BMI 之间的直接关联，但高柔性约束调节了抑制亚量表对 BMI（在 GATE/ALSPAC 中减少间接中介作用-5%至-11%）和外部饥饿（-5%）的影响。高刚性约束减少了 GATE/ALSPAC 中抑制亚量表的中介作用（-4%至-11%）和 GATE 中的外部饥饿（-3%）。