Edible Research Ltd, Ohoka, New Zealand.
Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Clin Nutr. 2023 Aug;42(8):1314-1321. doi: 10.1016/j.clnu.2023.06.019. Epub 2023 Jun 29.
BACKGROUND & AIM: The gut-brain axis is one of the proposed interactions between the brain and peripheral intestinal functions; of particular interest is the influence of food components on the gut-brain axis mediated via the gut microbiome. Probiotics and paraprobiotics have been proposed to interact with the intestinal environment and provide health benefits such as improving sleep quality. The aim of this research was to undertake a systematic literature review and meta-analysis to evaluate the current evidence regarding the effects of Lactobacillus gasseri CP2305 on sleep quality for the general population.
A systematic literature search was conducted of peer-reviewed articles published up to 04 November 2022. Randomised controlled trials were identified that investigated the effects of Lactobacillus gasseri CP2305 on sleep parameters in adults. Meta-analysis of the change in the Pittsburgh Sleep Quality Index (PSQI) global score was conducted. Quality assessments of individual studies were conducted using the Cochrane Risk of Bias and Health Canada tools.
Seven studies were included in the systematic literature review; six studies included data for meta-analysis to quantify the effect of L. gasseri CP2305 on sleep quality. The ingestion of L. gasseri CP2305 resulted in significant improvement in the PSQI global score compared to control (-0.77, 95% CI: -1.37 to -0.16, P = 0.01). In the two studies that included electroencephalogram (EEG) data, output was significantly improved for at least half of the measured EEG outcomes after consumption of L. gasseri CP2305. No serious concerns were found in the potential biases of included studies, indirectness of the included evidence, and other methodological issues.
The present systematic review and meta-analysis indicates significant improvement in sleep quality of adults with mild to moderate stress as an effect of daily consumption of L. gasseri CP2305. Based on existing evidence, the relationship between L. gasseri CP2305 and enhanced sleep quality is plausible, however further investigations are required to confirm the mechanisms of actions for this effect.
肠脑轴是大脑与肠道外围功能之间的一种拟议交互作用；特别感兴趣的是食物成分通过肠道微生物群对肠脑轴的影响。益生菌和拟益生菌被提议与肠道环境相互作用，并提供健康益处，例如改善睡眠质量。本研究旨在进行系统文献回顾和荟萃分析，以评估关于干酪乳杆菌 CP2305 对普通人群睡眠质量影响的现有证据。
对截至 2022 年 11 月 04 日发表的同行评审文章进行了系统文献检索。确定了调查干酪乳杆菌 CP2305 对成年人睡眠参数影响的随机对照试验。对匹兹堡睡眠质量指数（PSQI）总分变化进行了荟萃分析。使用 Cochrane 风险偏倚工具和加拿大卫生部工具对个别研究的质量进行了评估。
系统文献回顾纳入了 7 项研究；其中 6 项研究纳入了数据进行荟萃分析，以量化干酪乳杆菌 CP2305 对睡眠质量的影响。与对照组相比，摄入干酪乳杆菌 CP2305 可显著改善 PSQI 总分（-0.77，95%CI：-1.37 至-0.16，P=0.01）。在包含脑电图（EEG）数据的两项研究中，在摄入干酪乳杆菌 CP2305 后，至少有一半的 EEG 测量结果的输出得到了显著改善。在纳入研究的潜在偏倚、纳入证据的间接性和其他方法学问题方面，没有发现严重的问题。
本系统评价和荟萃分析表明，作为干酪乳杆菌 CP2305 每日摄入的结果，轻度至中度压力的成年人的睡眠质量有显著改善。基于现有证据，干酪乳杆菌 CP2305 与改善睡眠质量之间存在合理的关系，但需要进一步的研究来确认这种影响的作用机制。
