Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cytokine. 2023 Sep;169:156261. doi: 10.1016/j.cyto.2023.156261. Epub 2023 Jul 4.
The evaluation of diagnostic and prognostic biomarkers has always been a hot topic in various diseases. Considering that cardiovascular diseases (CVDs) have the highest mortality and morbidity rates in the world, various studies have been conducted so far to find CVD associated biomarkers, including cardiac troponin (cTn) and NT-proBNP. Cytokines are components of the immune system that are involved in the pathogenesis of CVD due to their contribution to the inflammation process. The level of cytokines varies in many cardiovascular diseases. For instance, the plasma level of IL-1α, IL-18, IL-33, IL-6 and IL-8 is positively correlated with atherosclerosis and that of some other interleukins such as IL-35 is negatively correlated with acute myocardial infarction or cardiac angina. Due to its pivotal role in the inflammation process, IL-1 super family is involved in many CVDs, including atherosclerosis. IL-20 among the interleukins of IL-10 family has a pro-atherogenic role, while others, such as IL-10 and IL-19, play an anti-atherogenic role. In the present review, we have collected the latest published evidence in this respect to discuss valuable cytokines from the diagnostic and prognostic stand point in CVDs.
诊断和预后生物标志物的评估一直是各种疾病的热门话题。鉴于心血管疾病 (CVDs) 在世界上的死亡率和发病率最高，迄今为止已经进行了各种研究来寻找与 CVD 相关的生物标志物，包括心肌肌钙蛋白 (cTn) 和 NT-proBNP。细胞因子是免疫系统的组成部分，由于它们对炎症过程的贡献，因此与 CVD 的发病机制有关。细胞因子的水平在许多心血管疾病中都有所不同。例如，IL-1α、IL-18、IL-33、IL-6 和 IL-8 的血浆水平与动脉粥样硬化呈正相关，而其他一些细胞因子如 IL-35 与急性心肌梗死或心绞痛呈负相关。由于其在炎症过程中的关键作用，IL-1 超家族参与了许多 CVD，包括动脉粥样硬化。IL-10 家族中的细胞因子 IL-20 具有促动脉粥样硬化作用，而其他细胞因子，如 IL-10 和 IL-19，则具有抗动脉粥样硬化作用。在本综述中，我们收集了这方面的最新发表证据，从诊断和预后的角度讨论了 CVD 中有价值的细胞因子。
