Christa Meisinger, Dennis Freuer, Philip Raake, Jakob Linseisen, Timo Schmitz
Epidemiology, Medical Faculty, University of Augsburg, University Hospital Augsburg, Stenglinstraße 2, 86156, Augsburg, Germany.
Department of Cardiology, Respiratory Medicine and Intensive Care, University Hospital Augsburg, Stenglinstraße 2, 86156, Augsburg, Germany.
Clin Proteomics. 2025 Feb 17;22(1):8. doi: 10.1186/s12014-025-09530-y.
To investigate the association between admission glucose and HbA1c values and inflammatory plasma proteins in hospitalized patients with acute ST-elevation myocardial infarction (STEMI).
This analysis was based on 345 STEMI patients recorded by the population-based Myocardial Infarction Registry Augsburg between 2009 and 2013. Using the OLINK inflammatory panel, a total of 92 protein biomarkers were measured in arterial blood samples, which were obtained within the scope of cardiac catheterization immediately after admission. The associations between admission glucose and HbA1c levels and the 92 protein markers were investigated using multivariable linear regression models.
Admission glucose showed significantly positive associations with the inflammatory markers IL-10, IL-8, IL-6, FGF-21, IL-7, ST1A1, MCP-1, 4E-BP1, SIRT2, STAMBP and IL-18R1 after Bonferroni adjustment. HbA1c values were only significantly associated with IL-18R1. In stratified analyses, admission glucose was not significantly associated with any plasma protein in the diabetes subgroup, while there were several protein markers that showed significantly positive associations with admission glucose in STEMI patients without known diabetes, namely IL-10, CCL20, IL-8, MCP-1 and IL-6.
Admission glucose in patients hospitalized due to an acute STEMI seems to be related to an inflammatory and immune-related response, expressed by an increase in inflammation-related plasma proteins in particular in non-diabetic patients with stress hyperglycemia. The present results may open new avenues for the development of biomarkers suitable as potential diagnostic or prognostic clinical markers.
探讨急性ST段抬高型心肌梗死（STEMI）住院患者入院时血糖和糖化血红蛋白（HbA1c）值与血浆炎症蛋白之间的关联。
本分析基于2009年至2013年奥格斯堡基于人群的心肌梗死登记处记录的345例STEMI患者。使用OLINK炎症检测板，在入院后立即进行心导管检查时采集的动脉血样本中测量了总共92种蛋白质生物标志物。使用多变量线性回归模型研究入院时血糖和HbA1c水平与92种蛋白质标志物之间的关联。
经Bonferroni校正后，入院时血糖与炎症标志物白细胞介素-10（IL-10）、白细胞介素-8（IL-8）、白细胞介素-6（IL-6）、成纤维细胞生长因子-21（FGF-21）、白细胞介素-7（IL-7）、ST1A1、单核细胞趋化蛋白-1（MCP-1）、4E-BP1、沉默信息调节因子2（SIRT2）、STAMBP和白细胞介素-18受体1（IL-18R1）呈显著正相关。HbA1c值仅与IL-18R1显著相关。在分层分析中，入院时血糖在糖尿病亚组中与任何血浆蛋白均无显著关联，而在无已知糖尿病的STEMI患者中，有几种蛋白质标志物与入院时血糖呈显著正相关，即IL-10、CC趋化因子配体20（CCL20）、IL-8、MCP-1和IL-6。
因急性STEMI住院患者的入院时血糖似乎与炎症和免疫相关反应有关，特别是在应激性高血糖的非糖尿病患者中，表现为炎症相关血浆蛋白增加。目前的结果可能为开发适合作为潜在诊断或预后临床标志物的生物标志物开辟新途径。
