Département de Neurosciences and Centre interdisciplinaire de recherche sur le cerveau et l'apprentissage (CIRCA), Université de Montréal, Québec, Canada; CIUSSS du Nord-de-l'Île-de-Montréal, Québec, Canada.
Département de Neurosciences and Centre interdisciplinaire de recherche sur le cerveau et l'apprentissage (CIRCA), Université de Montréal, Québec, Canada; CIUSSS du Nord-de-l'Île-de-Montréal, Québec, Canada; Department of Electrical Engineering, Polytechnique Montréal, Québec, Canada.
Prog Neurobiol. 2023 Sep;228:102492. doi: 10.1016/j.pneurobio.2023.102492. Epub 2023 Jul 5.
Rehabilitative and neuroprosthetic approaches after spinal cord injury (SCI) aim to reestablish voluntary control of movement. Promoting recovery requires a mechanistic understanding of the return of volition over action, but the relationship between re-emerging cortical commands and the return of locomotion is not well established. We introduced a neuroprosthesis delivering targeted bi-cortical stimulation in a clinically relevant contusive SCI model. In healthy and SCI cats, we controlled hindlimb locomotor output by tuning stimulation timing, duration, amplitude, and site. In intact cats, we unveiled a large repertoire of motor programs. After SCI, the evoked hindlimb lifts were highly stereotyped, yet effective in modulating gait and alleviating bilateral foot drag. Results suggest that the neural substrate underpinning motor recovery had traded-off selectivity for efficacy. Longitudinal tests revealed that the return of locomotion after SCI was correlated with recovery of the descending drive, which advocates for rehabilitation interventions directed at the cortical target.
脊髓损伤 (SCI) 后的康复和神经假体方法旨在重新建立对运动的自主控制。促进恢复需要对意志对动作的恢复的机制有深入的了解，但皮质命令重新出现与运动恢复之间的关系尚未得到很好的建立。我们在临床上相关的创伤性 SCI 模型中引入了一种提供靶向双皮质刺激的神经假体。在健康和 SCI 猫中，我们通过调整刺激的时间、持续时间、幅度和位置来控制后肢运动输出。在完整的猫中，我们揭示了一个大型运动程序库。在 SCI 后，诱发的后肢抬起非常刻板，但可以有效地调节步态并减轻双侧足拖曳。结果表明，运动恢复的神经基础已经牺牲了选择性以提高功效。纵向测试表明，SCI 后运动的恢复与下行驱动的恢复相关，这支持针对皮质靶标的康复干预。
