Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Trends Immunol. 2023 Aug;44(8):571-573. doi: 10.1016/j.it.2023.06.006. Epub 2023 Jul 4.
In a recent article, He et al. report that, in response to dietary protein antigens, mouse intestinal epithelial cells (IECs) accumulate a newfound 13-kDa N terminus of gasdermin D (GSDMD-N13), cleaved by caspase-3/7. Unlike the pyroptotic 30-kDa fragment, GSDMD-N13 translocates to the nucleus, inducing CIITA and major histocompatibility complex class II (MHCII) expression to promote type 1 regulatory T (T1r) cell development, thus revealing its role in balancing immunity and food tolerance.
在最近的一篇文章中，何等人报道称，在响应膳食蛋白抗原时，小鼠肠上皮细胞（IECs）积累gasdermin D（GSDMD）的新的 13kDa N 末端（GSDMD-N13），该片段被 caspase-3/7 切割。与致炎的 30kDa 片段不同，GSDMD-N13 易位到细胞核，诱导 CIITA 和主要组织相容性复合体 II（MHCII）的表达，以促进 1 型调节性 T（T1r）细胞的发育，从而揭示其在平衡免疫和食物耐受中的作用。
