Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, 421001, China.
J Mol Med (Berl). 2023 Aug;101(8):947-959. doi: 10.1007/s00109-023-02345-0. Epub 2023 Jul 6.
Group 2 innate lymphoid cells (ILC2s), characterized by a lack of antigen receptors, have been regarded as an important component of type 2 pulmonary immunity. Analogous to Th2 cells, ILC2s are capable of releasing type 2 cytokines and amphiregulin, thus playing an essential role in a variety of diseases, such as allergic diseases and virus-induced respiratory diseases. Interferons (IFNs), an important family of cytokines with potent antiviral effects, can be triggered by microbial products, microbial exposure, and pathogen infections. Interestingly, the past few years have witnessed encouraging progress in revealing the important role of IFNs and IFN-producing cells in modulating ILC2 responses in allergic lung inflammation and respiratory viral infections. This review underscores recent progress in understanding the role of IFNs and IFN-producing cells in shaping ILC2 responses and discusses disease phenotypes, mechanisms, and therapeutic targets in the context of allergic lung inflammation and infections with viruses, including influenza virus, rhinovirus (RV), respiratory syncytial virus (RSV), and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2).
2 型固有淋巴细胞（ILC2s）缺乏抗原受体，被认为是 2 型肺免疫的重要组成部分。类似于辅助性 T 细胞 2（Th2），ILC2 能够释放 2 型细胞因子和双调蛋白，从而在多种疾病中发挥重要作用，如过敏疾病和病毒引起的呼吸道疾病。干扰素（IFN）是一类具有强大抗病毒作用的细胞因子，可被微生物产物、微生物暴露和病原体感染所触发。有趣的是，过去几年在揭示 IFN 和 IFN 产生细胞在调节过敏肺炎症和呼吸道病毒感染中 ILC2 反应方面取得了令人鼓舞的进展。本综述强调了 IFN 和 IFN 产生细胞在塑造 ILC2 反应中的作用的最新进展，并讨论了过敏肺炎症和病毒感染（包括流感病毒、鼻病毒（RV）、呼吸道合胞病毒（RSV）和严重急性呼吸综合征冠状病毒 2（SARS-CoV-2））背景下的疾病表型、机制和治疗靶点。
