Department of Biotechnology, PSG College of Technology, Coimbatore, India.
Computational Biology Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, India.
Arch Microbiol. 2023 Jul 6;205(8):276. doi: 10.1007/s00203-023-03618-5.
Proteases are enzymes that catalyze the amide bond dissociation in polypeptide and protein peptide units. They are categorized into seven families and are responsible for a wide spectrum of human ailments, such as various types of cancers, skin infections, urinary tract infections etc. Specifically, the bacterial proteases cause a huge impact in the disease progression. Extracellular bacterial proteases break down the host defense proteins, while intracellular proteases are essential for pathogens virulence. Due to its involvement in disease pathogenesis and virulence, bacterial proteases are considered to be potential drug targets. Several studies have reported potential bacterial protease inhibitors in both Gram-positive and Gram-negative disease causing pathogens. In this study, we have comprehensively reviewed about the various human disease-causing cysteine, metallo, and serine bacterial proteases as well as their potential inhibitors.
蛋白酶是一种能够催化多肽和蛋白质肽单元酰胺键断裂的酶。它们被分为七大家族，与多种人类疾病有关，如各种类型的癌症、皮肤感染、尿路感染等。具体来说，细菌蛋白酶会对疾病进展产生巨大影响。细胞外细菌蛋白酶会分解宿主防御蛋白，而细胞内蛋白酶则是病原体毒力所必需的。由于其参与疾病的发病机制和毒力，细菌蛋白酶被认为是潜在的药物靶点。多项研究报告了革兰氏阳性和革兰氏阴性致病菌中潜在的细菌蛋白酶抑制剂。在这项研究中，我们全面回顾了各种导致人类疾病的半胱氨酸、金属和丝氨酸细菌蛋白酶及其潜在抑制剂。
