Division of Pediatrics, Department of Neonatology, University Medical Centre Ljubljana, Bohoričeva 20, 1000 Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.
Cereb Cortex. 2023 Aug 23;33(17):9927-9935. doi: 10.1093/cercor/bhad255.
Impaired cognitive functioning after perinatal stroke has been associated with long-term functional brain network changes. We explored brain functional connectivity using a 64-channel resting-state electroencephalogram in 12 participants, aged 5-14 years with a history of unilateral perinatal arterial ischemic or haemorrhagic stroke. A control group of 16 neurologically healthy subjects was also included-each test subject was compared with multiple control subjects, matched by sex and age. Functional connectomes from the alpha frequency band were calculated for each subject and the differences in network graph metrics between the 2 groups were analyzed. Our results suggest that the functional brain networks of children with perinatal stroke show evidence of disruption even years after the insult and that the scale of changes appears to be influenced by the lesion volume. The networks remain more segregated and show a higher synchronization at both whole-brain and intrahemispheric level. Total interhemispheric strength was higher in children with perinatal stroke compared with healthy controls.
围产期卒中后认知功能障碍与长期功能性大脑网络变化有关。我们使用 64 通道静息态脑电图对 12 名 5-14 岁的单侧围产期动脉缺血性或出血性卒中患者进行了脑功能连接研究。还纳入了 16 名神经健康对照组，每个测试对象均与多个性别和年龄匹配的对照组进行比较。为每个受试者计算了阿尔法频带的功能连接组，并分析了两组之间网络图形指标的差异。我们的研究结果表明，围产期卒中儿童的大脑功能网络即使在损伤多年后仍显示出中断的迹象，而且变化的程度似乎受到病变体积的影响。网络的分离程度更高，在全脑和半球内水平的同步性更高。与健康对照组相比，围产期卒中患儿的大脑半球间总强度更高。
