Ahmed Rania, Blum Kenneth, Thanos Panayotis K
Department of Psychology, State University at Buffalo, Buffalo, NY, USA.
Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY, USA.
Curr Pharm Des. 2023;29(27):2124-2139. doi: 10.2174/1381612829666230706143026.
Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in the loss of hundreds of thousands of lives annually. Besides alcohol and opioid use and misuse, there has been an increase in illicit abuse of psychostimulants. Epigenetics is a relatively novel area of research that studies heritable alterations in gene expression. Long-term administration of psychoactive drugs may lead to transcriptional changes in brain regions related to drug-seeking behaviors and rewards that can be passed down transgenerationally. Epigenetic biomarkers such as DNA methylation and histone modifications contribute to disease diagnoses. This review aims to look at the epigenetic modifications brought forth by psychoactive drug abuse.
目前，在全球范围内，我们正面临着最严重的精神活性药物滥用流行，每年导致数十万人丧生。除了酒精和阿片类药物的使用及滥用外，精神兴奋剂的非法滥用也有所增加。表观遗传学是一个相对较新的研究领域，它研究基因表达的可遗传变化。长期使用精神活性药物可能会导致与药物寻求行为和奖赏相关的脑区发生转录变化，这种变化可以跨代传递。DNA甲基化和组蛋白修饰等表观遗传生物标志物有助于疾病诊断。本综述旨在探讨精神活性药物滥用所带来的表观遗传修饰。
