Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Oberschleißheim, Germany.
Department of Radiation Oncology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Med Phys. 2023 Aug;50(8):4734-4743. doi: 10.1002/mp.16587. Epub 2023 Jul 6.
The production of individualized anthropomorphic phantoms via three-dimensional (3D) printing methods offers promising possibilities to assess and optimize radiation exposures for specifically relevant patient groups (i.e., overweighed or pregnant persons) that are not adequately represented by standardized anthropomorphic phantoms. However, the equivalence of printed phantoms must be demonstrated exemplarily with respect to the resulting image contrasts and dose distributions.
To reproduce a conventionally produced anthropomorphic phantom of a female chest and breasts and to evaluate their equivalence with respect to image contrasts and absorbed doses at the example of a computed tomography (CT) examination of the chest.
In a first step, the effect of different print settings on the CT values of printed samples was systematically investigated. Subsequently, a transversal slice and breast add-ons of a conventionally produced female body phantom were reproduced using a multi-material extrusion-based printer, considering six different types of tissues (muscle, lung, adipose, and glandular breast tissue, as well as bone and cartilage). CT images of the printed and conventionally produced phantom parts were evaluated with respect to their geometric correspondence, image contrasts, and absorbed doses measured using thermoluminescent dosimeters.
CT values of printed objects are highly sensitive to the selected print settings. The soft tissues of the conventionally produced phantom could be reproduced with a good agreement. Minor differences in CT values were observed for bone and lung tissue, whereas absorbed doses to the relevant tissues were identical within the measurement uncertainties.
3D-printed phantoms are with exception of minor contrast differences equivalent to their conventionally manufactured counterparts. When comparing the two production techniques, it is important to note that conventionally manufactured phantoms should not be considered as absolute benchmarks, as they also only approximate the human body in terms of its absorption, and attenuation of x-rays as well as its geometry.
通过三维(3D)打印方法制作个体化的拟人化模型为评估和优化特定相关患者群体(即超重或孕妇)的辐射暴露提供了有前途的可能性,这些患者群体在标准化的拟人化模型中没有得到充分体现。然而,必须证明打印的模型在图像对比度和剂量分布方面具有等效性。
以胸部 CT 检查为例,复制一个传统制作的女性胸部和乳房的拟人化模型,并评估其在图像对比度和吸收剂量方面的等效性。
在第一步中,系统地研究了不同打印设置对打印样本 CT 值的影响。随后,使用基于多材料挤压的打印机复制了一个传统制作的女性身体模型的横切片和乳房附件,考虑了六种不同类型的组织(肌肉、肺、脂肪和乳腺组织,以及骨和软骨)。对打印和传统制作的模型部分的 CT 图像进行评估,包括其几何对应性、图像对比度以及使用热释光剂量计测量的吸收剂量。
打印物体的 CT 值对所选打印设置非常敏感。传统制作的模型中的软组织可以很好地再现。在骨组织和肺组织中观察到 CT 值的微小差异,而在测量不确定度内,相关组织的吸收剂量是相同的。
3D 打印的模型除了对比度略有差异外,与传统制造的模型等效。在比较两种生产技术时,重要的是要注意,传统制造的模型不应被视为绝对的基准,因为它们在 X 射线的吸收、衰减以及几何形状方面也仅近似于人体。